Actor/Actress
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Description
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Character
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Clark Gregg
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A S.H.I.E.L.D. agent who oversees many of the division's field operations
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Phil Coulson
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Ming-Na Wen
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A S.H.I.E.L.D. ace pilot and weapons expert, nicknamed "the Cavalry"
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Melinda May
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Brett Dalton
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A Hydra agent who poses as a S.H.I.E.L.D. black ops specialist
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Grant Ward
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Chloe Bennett
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An Inhuman hacktivist and S.H.I.E.L.D. recruit who eventually becomes an agent with the ability to sense vibrations and create earthquakes
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Daisy "Skye" Johnson / Quake
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Iain De Caestecker
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An agent of S.H.I.E.L.D. who specializes in engineering, especially weapons technology
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Leo Fitz
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Elizabeth Henstridge
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A S.H.I.E.L.D. biochemist who specializes in life sciences (both human and alien)
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Jemma Simmons
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Nick Blood
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A mercenary before agreeing to join S.H.I.E.L.D.
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Lance Hunter
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Adrianne Palicki
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Hunter's ex-wife and an agent of S.H.I.E.L.D. who spent time undercover within Hydra
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Bobbi Morse
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Henry Simmons
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A S.H.I.E.L.D. mechanic with a distrust of the alien and superhuman
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Alfonso "Mack" MacKenzie
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Luke Mitchell
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An Inhuman with the ability to manipulate electrical charges
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Lincoln Campbell
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Brett Dalton
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An alien who took the body of Grant Ward who wants to make an army of Inhumans
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Hive
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J. August Richards
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An ordinary man that was artificially enhanced with the Extremis-containing Centipede serum by Project Centipede who later joins S.H.I.E.L.D, but is caught in an explosion and awakens without his right leg and under the control of the "Clairvoyant", who gives him a bionic prosthetic limb as part of "Project Deathlok", but after the defeat of Centipede and the "Clairvoyant", he works for Coulson covertly, and aids in the take down of Hydra leader Dr. List
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Mike Peterson / Deathlok
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David Conrad
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A wealthy industrialist/philanthropist and the CEO of Quinn Worldwide, who is involved with The Clairvoyant, who, after acquiring the Deathlok leg from Cybertek for Mike Peterson, and shooting Skye in the stomach, is detained by S.H.I.E.L.D. and taken to The Fridge, where he is later released by John Garrett following the Hydra reveal, where he attempts to sell Deathlok soldiers to the U.S. military as a replacement for S.H.I.E.L.D., but after Garrett is defeated, he goes into hiding with his gravitonium
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Ian Quinn
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Ruth Negga
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A woman who was raised by Calvin Zabo, and grew up with stories of her heritage as an Inhuman, and her potential to be more, and after becoming the Project Centipede recruiter due to her interest in powered people, she works with Hydra in an attempt to replicate the GH-325 serum that was used to resurrect Coulson, but she eventually goes through Terrigenesis, gaining the power of precognition, but also a monstrous appearance, where she comes to accept her new circumstances, and later allows Jiaying to kill her so that Skye can learn of the former's true intent
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Raina
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Saffron Burrows
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She is the high-ranking S.H.I.E.L.D. agent who runs The Hub, a S.H.I.E.L.D. base, but after discovering that Hydra exists within S.H.I.E.L.D., she turns on Coulson, believing him to be a double agent, however, Garrett soon reveals himself to be the traitor, and she works with Coulson to detain him, but is killed by Ward when he reveals himself to be a member of Hydra to save Garrett from imprisonment
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Victoria Hand
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Christine Adams
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The director of the S.H.I.E.L.D. Academy of Science and Technology who joins the leadership of the "real S.H.I.E.L.D." following the fall of the original organization, in which she fought one of Hydra's enhanced soldiers, developing a distrust in the superhumans where she takes over command of the S.H.I.E.L.D. warship The Iliad following the death of Robert Gonzales
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Anne Weaver
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Bill Paxton
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A S.H.I.E.L.D. agent who was left for dead by that organization, and only survived by becoming the first Deathlok, and after he joined Hydra, he became "The Clairvoyant", leader of the Centipede group, and was focused on discovering the secret to Coulson's resurrection given the impending failure of his now outdated Deathlok technology while under the guise of a S.H.I.E.L.D. agent tasked with capturing and interrogating Ian Quinn, Garrett joins in Coulson's efforts to find the GH-325 drug, where, based on his findings, Raina is able to synthesize a version of the drug, which does save his life, however, after Hydra is revealed to have infiltrated S.H.I.E.L.D. and Garret is outed as the Clairvoyant, Coulson kills him by disintegration
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John Garrett / The Clairvoyant
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B. J. Britt
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He worked with Garrett until the Hydra reveal, after which he joins Coulson's team, where he perishes when he becomes trapped in the chamber Skye and Raina undergo Terrigenesis in, as he was not descended from Inhumans
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Antoine Triplett
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Adrian Pasdar
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A United States Air Force colonel and later brigadier general who hunts active S.H.I.E.L.D. agents after the organization's disbandment, but Coulson earns his trust over time, and the two soon enter an agreement in which S.H.I.E.L.D. provides the government with sensitive assets and helps with the take down of Hydra in exchange for being left alone and he is made head of the Advanced Threat Containment Unit (ATCU) following the death of Rosalind Price, an arrangement which sees him reluctantly working for Coulson
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Glenn Talbot
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Patton Oswalt
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S.H.I.E.L.D. agents, with one being stationed at Providence base and assists Coulson in the wake of Hydra's emergence, but is soon killed by Ward, and Coulson and his team meet his brothers at the Playground base soon after, where they work with Coulson on the mysterious Theta Protocol, the maintenance of a S.H.I.E.L.D. helicarrier for use by Nick Fury
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Eric, Billy, and Sam Koenig
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Actor/Actress
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Description
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Character
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Kyle MacLachlan
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When he was a young doctor, he met the Inhuman Jiaying while in China, and soon, the two eventually married, and had a daughter, Daisy, but after Jiaying was torn apart by Hydra, and Daisy was taken by S.H.I.E.L.D. agents, he stitched his wife back together, found innocent people whose life-force was used to bring Jiaying back to life, and began searching for his daughter, at some point changing his last name, and he also began experimenting on himself in an attempt to be stronger, blaming himself for not protecting his family, but Jiaying eventually abandoned the search to live a peaceful life with other Inhumans like her, but he continued, eventually meeting Daisy—now going by Skye—and over time forming a bond with her, despite her hatred for his past actions, and Coulson later convinces him that Jiaying is a monster who has forced him to do terrible things, and when Jiaying starts a war with S.H.I.E.L.D. that leads to a face down with Skye, he kills Jiaying and S.H.I.E.L.D. then wipes his memory to allow him to live a peaceful life
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Calvin Zabo
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Reed Diamond
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A high ranking Nazi officer and an elite member of Hydra in 1945, who was experimenting on the Diviner when his base was taken by the SSR and he was imprisoned for life, before being released by Alexander Pierce in 1988, he discovered that a woman unaffected by the Diviner, Jiaying, had apparently not aged in four decades, which, upon dissecting her, he discovered the secret to her youthfulness and used it to de-age himself and, taking the name Daniel Whitehall, he became the North American leader of Hydra following Pierce's death, fighting against Coulson's S.H.I.E.L.D. while remaining interested in the Diviner and other alien matters, but he is killed by Coulson while trying to unlock the true power of the Diviner
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Daniel Whitehall
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Simon Kassianides
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Being the right-hand man to Whitehall, he is instrumental in the brainwashing of Hydra's subjects, including S.H.I.E.L.D. agent Kara Palamas, who later gets revenge by brainwashing him herself, and, now loyal to Palamas and Ward, he sacrifices his life to save the latter when Simmons tries to kill him
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Sunil Bakshi
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Maya Stojan
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A S.H.I.E.L.D. agent betrayed to Hydra by the then undercover Morse and subjected to brainwashing by Bakshi and Whitehall, who, now Hydra-loyal, used a nanomask to take on the appearance of May, and when the latter electrocutes her whilst in this disguise, she is left stuck as May, but deformed, but after Coulson kills Whitehall, she works with Ward, the two forming a romantic relationship while the latter does everything in his power to bring her "closure", so they get her nanomask repaired so that she can become whoever she wishes, brainwash Bakshi, and kidnap Morse in an attempt to force a confession out of her, but when May and Hunter come to rescue Morse, Ward accidentally kills her while she is in disguise as May
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Kara Palamas / Agent 33
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Dichen Lachman
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The Inhuman wife of Zabo, and Daisy's mother, who does not age and can heal rapidly thanks to an elder of her village giving their life each year, and she is pieced back together by Zabo after Whitehall dissects her to discover the secret to her abilities, she is never the same, and goes to great lengths to find her daughter, now willingly taking innocent lives to feed her abilities, having no regard for humans, and, eventually, she tries to escape this new persona by founding Afterlife, a haven for Inhumans, and when Daisy (going by Skye) journeys to Afterlife, she happily becomes her mentor, however, when S.H.I.E.L.D. discovers the location of Afterlife, she starts a war with them, and attempts to kill all humans with artificial Terrigen crystals, and even tries to drain Skye's life when the former turns on her, but is stopped by Zabo, who kills her
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Jiaying
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Jamie Harris
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An eyeless Inhuman with the ability to teleport and emit force fields, and his transition to an Inhuman was tended to by Jiaying, and he remained loyal to her in his adult life, ensuring that only a select few could enter and/or leave Afterlife, and joining with her in her war against S.H.I.E.L.D., but he is killed by Fitz while trying to spread Terrigen mist through the ventialtion of The Iliad during a fight where Fitz was able to minimize the distance of Gordon's teleportation
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Gordon
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Blair Underwood
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May's ex-husband and a psychologist at Culver University who assesses gifted people for S.H.I.E.L.D., but while vacationing with May to try and rekindle their relationship, he is exposed to Terrigen which unlocks Inhuman abilities within him, and he becomes an Inhuman who uses energy abilities to hunt and kill 'unworthy' Inhumans, but he surrenders himself to S.H.I.E.L.D. before the transformation becomes permanent, and manages to say goodbye to May before completely becoming him, but soon S.H.I.E.L.D. sends him to fight Hive, hoping that his Inhuman purpose is to destroy the latter, though this is not the case, he is able to purge Daisy Johnson of Hive's control, before being killed by Hellfire
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Andrew Garner / Lash
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Edward James Olmos
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An elderly S.H.I.E.L.D. agent, tactician, and the commander of The Iliad during the fall of S.H.I.E.L.D. who is tasked with protecting the Kree monolith, and he is convinced not to destroy the ship (to prevent Hydra from claiming the monolith) so that the hundreds of agents on board may live, disobeying Fury's orders, and subsequently becomes a founding member of the "real S.H.I.E.L.D." alongside Anne Weaver, Tomas Calderon, and Agent Oliver, but he remains distrustful of secrets and all things alien, even after agreeing to keep Coulson on as Director of a new, unified S.H.I.E.L.D., but still attempts to negotiate with Jiaying and the Inhumans peacefully, however, Jiaying kills him and shoots herself, claiming that he attacked her, in order to start a war against S.H.I.E.L.D.
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Robert Gonzales
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Alicia Vela-Bailey
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A duplicating Inhuman who was loyal to Jiaying until she learned that the latter started the war with S.H.I.E.L.D., and after Jiaying's death, she helps S.H.I.E.L.D. until she falls under the influence of Hive, but she is later murdered by a Kree reaper
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Alisha Whitley
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Daz Crawford
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A member of Hydra who becomes second-in-command to Ward until he is killed by Morse
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Kebo
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Constance Zimmer
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The head of the ATCU as it crosses paths with S.H.I.E.L.D. in the hunt for Inhumans, but after developing a romantic relationship with Coulson, she is killed by Ward
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Rosalind Price
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Andrew Howard
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A ATCU agent and former Marine loyal to Price who is killed by Giyera
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Luther Banks
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Juan Pablo Raba
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An Inhuman and former construction worker with the ability to melt certain metals who is recruited by S.H.I.E.L.D. for Daisy Johnson's Secret Warriors team
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Joey Gutierrez
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Spencer Treat Clark
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The son of Hydra leader Wolfgang von Strucker, who is recruited to Hydra by Ward after Wolfgang's death, but after failing to follow Ward's orders and kill Garner, he is left in a vegetative state by Kebo, and is taken into S.H.I.E.L.D. custody
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Werner von Strucker
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Powers Boothe
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A former member of the World Security Council and secret leader of Hydra who ascended to power following the death of his father in 1970, he was joined by his brother Nathaniel, but the two soon learned of a trick their father used to avoid being sacrificed to Hive, and when he followed suit, Nathaniel was sacrificed, and he successfully opens the portal to allow Hive to return to Earth, but Hive reveals that he has retained Nathaniel's memories, and punishes him by murdering his daughter Stephanie, so after being captured by S.H.I.E.L.D., he cooperates with Coulson against Hive, but he is murdered by Johnson while she is controlled by Hive
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Gideon Malick
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Mark Dacascos
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A telekinetic Inhuman and head of security for the ATCU, secretly loyal to Malick, but he is eventually swayed over to Hive's side, until he is killed by Fitz
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Giyera
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Natalia Cordova-Buckley
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A Colombian Inhuman who can move at a super speed for a beat of her heart, before returning to the point she started moving from, and she comes into contact with S.H.I.E.L.D. when they investigate her for stealing local, corrupt police's weapons, but she grows close to Mack, who nicknames her "Yo-Yo", and eventually agrees to join the Secret Warriors
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Elena "Yo-Yo" Rodriguez
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Axle Whitehead
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An Inhuman who was refused the right of Terrigenesis by Jiaying and banished from Afterlife, and Johnson subjects James to the transformation while under the influence of Hive, giving James the ability to imbue objects with fire
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James / Hellfire
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John Hannah
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A transhumanist who believes in the improvement of humanity through enhancement, and, due to his studies of parasites, Fitz and Simmons seek his help with counteracting Hive's abilities, but he is kidnapped by Hive first to help recreate the original Kree experiment that created the Inhumans, but after a S.H.I.E.L.D. raid on Hive's base, he escapes and agrees to cooperate with Coulson and Talbot, and, after being acquitted, he begins work on transferring his artificial intelligence AIDA to a Life Model Decoy, an old S.H.I.E.L.D. project
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Holden Radcliffe
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