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Atherosclerosis

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Last updated: April 05, 2019
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Hint
Answer
What is the main cause of thrombosis in veins? (due to slow blood flow)
Stasis
What is the eponymous name for the laminations that occur in thrombi in arteries?
Lines of Zahn
What is the process in which new blood vessels form through the thrombus called?
Recanalisation
What is the medical term for too few platelets?
Thrombocytopaenia
What is the most internal layer of a large artery?
Tunica intima
What is the most external layer of an artery?
Tunica adventitia
What is described? A disease of the intima of large and medium sized arteries.
Atherosclerosis
What disease may be caused by the above but instead is purely a loss of elasticity and physical hardening of the arterial wall, from any cause?
Arteriosclerosis
What is considered as good cholesterol as it moves cholesterol from peripheral tissues to the liver for excretion through bile?
High-density lipoprotein/HDL
Hint
Answer
What pathway leads to production of foam cells due to macrophages aiming to take up modified lipoproteins?
Scavenger receptor pathway
What is the banner term for an abnormal concentration of lipoproteins in the blood. this can include hypercholestrolaemia or a secondary disease leading to it (diabetes).
Dislipoproteinaemia
By what process to macrophages take up oxidised lipoproteins to become foam cells?
Phagocytosis
Macrophages activate smooth muscle using molecules (PDGF and FGF) this leads to it turning from a contractile to what type of phenotype?
Synthetic
What are the precussors to atherosclerosis that can be seen on the intima of arteries of teenagers?
Fatty dots/streaks
In the intima of fibro-fatty atherosclerotic plaques there are three key regions, these are. Fibrous cap, lipid core and what third (containing foam cells and where angiogenesis may take place)?
Shoulder
What is described? A localised enlargement of an artery?
Aneurysm
What is gradual narrowing of the lumen due to atherosclerosis referred to as?
Stenosis
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