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Most Prescribed Medications in the USA

List the top 10 most prescribed and the top 10 most costly medications for Medicare Part D patients in the United States.
source: data.cms.gov
as of 2021 data
Quiz by herosinger
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Last updated: February 15, 2024
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First submittedOctober 4, 2017
Times taken190
Average score25.0%
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Medicare Claims
Total Spending
Drug
Drug Class
Average Cost / Patient
61.1M
$836M
Atorvastatin
Cardiovascular
$56 / yr
44.2M
$310M
Amlodipine
Cardiovascular
$30 / yr
38.4M
$728M
Levothyroxine
Endocrine
$91 / yr
36.1M
$260M
Lisinopril
Cardiovascular
$30 / yr
33.0M
$622M
Gabapentin
Neurology
$90 / yr
29.4M
$393M
Losartan
Cardiovascular
$55 / yr
28.3M
$439M
Omeprazole
Gastrointestinal
$62 / yr
26.2M
$587M
Metoprolol
Cardiovascular
$95 / yr
24.2M
$182M
Metformin
Endocrine
$31 / yr
23.4M
$140M
Furosemide
Cardiovascular
$25 / yr
Medicare Claims
Total Spending
Drug
Drug Class
Average Cost / Patient
17.1M
$12.58B
Eliquis
Cardiovascular
$4,024 / yr
344K
$5.89B
Revlimid
Cancer
$129,242 / yr
6.4M
$5.23B
Xarelto
Cardiovascular
$4,154 / yr
3.7M
$4.70B
Trulicity
Endocrine
$7,084 / yr
4.5M
$4.06B
Januvia
Endocrine
$4,344 / yr
3.8M
$3.74B
Jardiance
Cardiovascular
$4,224 / yr
231K
$3.15B
Imbruvica
Cancer
$120,958 / yr
375K
$2.91B
Humira Pen
Antirheumatic
$56,752 / yr
4.6M
$2.83B
Lantus Solostar
Endocrine
$2,685 / yr
2.0M
$2.62B
Ozempic
Endocrine
$5,717 / yr
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