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Actor/Actress
Description
Character
Ryan Reynolds
A mercenary who is subjected to an experimental regenerative mutation to cure his cancer, which gives him accelerated healing superpowers, but severely scars his body
Wade Wilson / Deadpool
Morena Baccarin
An escort and Wilson's girlfriend
Vanessa
Ed Skrein
An artificially-mutated member of Weapon X, the program that creates Deadpool
Francis Freeman / Ajax
T.J. Miller
Wilson's best friend
Weasel
Gina Carano
An artificially-mutated member of Weapon X who possesses superhuman levels of strength, stamina and speed
Angel Dust
Leslie Uggams
An elderly blind woman and Deadpool's roommate
Blind Al
Brianna Hildebrand
A teenage X-Men trainee who possesses the mutant power to detonate atomic bursts from her body
Negasonic Teenage Warhead
Stefan Kapicic
An X-Man with the mutant ability to transform his entire body into organic steel