Actor/Actress
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Description
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Character
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Tobey Maguire
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A brilliant physics student at Columbia University and photographer for the Daily Bugle who gets spider-like abilities from a radioactive spider and uses them to take up the persona of a spider-based vigilante protecting New York City from its criminal underworld
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Peter Parker / Spider-Man
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Kirsten Dunst
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A Broadway actress and Peter's childhood girlfriend
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Mary Jane Watson
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James Franco
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The dedicated son of Norman Osborn and Peter's estranged best friend, who believes Spider-Man murdered his father, but after learning Peter is Spider-Man and his father was the Green Goblin, he tends to battle Peter directly as a psychopathic assassin armed with the same equipment as his father
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Harry Osborn / New Goblin
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Thomas Haden Church
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A small-time thug with an estranged wife and sick daughter, whose struggle to rob for money to get his daughter treatment lures him into a freak accident that alters him into a master sand manipulator hunted by Spider-Man since he was Peter's uncle Ben's true killer
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Flint Marko / Sandman
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Topher Grace
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A rival Daily Bugle photographer who is exposed by Peter for creating a fake image of Spider-Man, and is ready for revenge when he bonds with the symbiote, turning him into monstrous being with the same spider-like powers
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Eddie Brock / Venom
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Bryce Dallas Howard
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Peter's lab partner and good friend, who is saved by Spider-Man from falling to her death
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Gwen Stacy
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Rosemary Harris
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Peter's aunt, who gives her nephew her engagement ring so he can propose to Mary Jane, and teaches him forgiveness
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May Parker
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J.K. Simmons
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The aggressive chief of the Daily Bugle who despises Spider-Man
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J. Jonah Jameson
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James Cromwell
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Gwen's father and a New York City Police Department Captain
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Captain George Stacy
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Theresa Russel
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Flint's wife
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Emma Marko
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Dylan Baker
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Peter's college physics professor who examines a piece of the symbiote and tells Peter it "amplifies characteristics of its host… especially aggression"
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Dr. Curt Connors
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Bill Nunn
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A longtime employee at the Daily Bugle
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Joseph "Robbie" Robertson
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Elizabeth Banks
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Jameson's receptionist at the Daily Bugle
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Betty Brant
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Ted Raimi
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A Daily Bugle employee who suggests a catchphrase to Jameson
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Hoffman
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Perla Haney-Jardine
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Flint and Emma's sick daughter
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Penny Marko
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Willem Dafoe
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The hallucination of Harry's late father who encourages his son to destroy Spider-Man
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Norman Osborn / Green Goblin
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Cliff Robertson
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Peter's deceased uncle
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Ben Parker
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Elya Baskin
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Peter's landlord who is greedy for Peter's rent
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Dr. Ditkovitch
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Mageina Tovah
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The unassuming daughter of Dr. Ditkovitch
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Ursula Ditkovitch
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Michael Papajohn
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A carjacker who was believed to have murdered Peter's uncle Ben
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Dennis Carradine
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Joe Manganiello
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Mary Jane's former boyfriend and a bully to Peter from the original film
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Flash Thompson
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