Cancer Drugs

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Quiz by jlande12
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Last updated: January 31, 2018
First submittedJanuary 31, 2018
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Beta tubulin assembly
vincristine
BRAF inhibitor
vemuramab
beta tubulin- no disassembly
paclitaxel
topoisomerase 1 inhibitor (DLT myelosuppression)
topotecan
inhibitor of CDK-4, CDK-6, and inactivates RB protein
palbociclib
topoisomerase II inhibitor (toxicity includes myelosuppression and 2nd leukemia)
etoposide
multiple receptor tryosine kinase inhibitor (inhibits VEGFR, PDGFR)
sunitinib
TKI that inhibits VEGF and RAF
sorafenib
intercalates DNA, inhibits topo 2, chelates iron
doxorubicin
binds DNA, resulting in single and double strand breaks following free radical formation and inhibition of DNA sythesis
bleomycin
intercalates DNA, inhibits topoisomerase 2, no free radical formation
mitoxantrone
mTor inhibitor
temsirolimus
TKI that targets EGFR
erlotinib
targets PD-1 on T-cells
nivolumab
Hint
Answer
androgen inhibitor
bicalutamide
targets HER-2
Trastuzumab
inhibits proteosome
bortezumab
targets CD20 on B-cells
rituximab
interacts with DNA at GC sites
dactinomycin
targets CTLA-4
ipilmumab
estogen inhibitor
tamoxifen
targets VEGR (required for angiogenesis)
bevacizumab
agonist at pituitary GnRH receptors; leads to testosterone suppresion
leuprolide
topoisomerase I inhibitor (active metabolite SN38)
irinotecan
GnRH antagonist that causes testosterone suppression
degarelix
inhibitor of the tyrosine kinase domain of Bcr-Abl (philadelphia chromosome)
imatinib
aromatase inhibitor
letrozole
potent inhibitor of angiogenesis
thalidomide
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