Statistics for anticancer drugs

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General Stats
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General Stats

This quiz has been taken 13 times
The average score is 13 of 35

Answer Stats

Hint	Answer	% Correct
	chemotherapy	88%
what are the treatment options for cancer?	surgery	75%
	anti-metabolites	63%
what are their adverse effects?	bone marrow suppression, hair loss, rash, GI upset, allergy, dilated cardiomyopathy, hand-foot syndrome, inflamed bowel	63%
what are the main characteristics of cancer?	cells will proliferate without restraint	63%
what are the types of anticancer drugs?	genotoxic agents	63%
	GI upset, vomiting, cystitis, bone marrow suppression, hair loss, low white blood cell count, increased risk of infertility, increased risk of other cancers	63%
	GI upset, vomiting, hair loss, fatigue, muscle pain, hand-foot syndrome, bone marrow suppression, increased risk of infection, allergy, teratogenic effects	63%
	radiotherapy	63%
	cells will invade and colonise spaces normally reserved for other cells	50%
	immunotherapy	50%
	interferes with the mechanics of cell division, stopping it during early mitosis by either binding to tubulin monomers and stop them polymerizing into microtubules or binding to microtubules to stabilise them and inhibit depolymerization	50%
	other cells rapidly divide also - not just cancer cells	50%
what are the common mechanisms of resistance by cancer cells to drug therapies?	over- expression of the P-glycoprotein efflux pump involved in transporting drugs out of cells	50%
	spindle inhibitors	50%
	endocrine interference drugs	38%
	GI upset, vomiting, headache, fatigue, abnormal blood cell count, liver damage, renal impairment, inflamed mouth, teratogenic effects	38%
what are their mechanisms of action?	(intercalating agent) interacts directly with DNA by inserting itself between base pairs due to the planar aromatic chromophore in its structure	38%
	paclitaxel	38%
	(spindle inhibitor that specifically targets tubulin) disrupts mitotic spindle assembly and chromosome segregation, blocking cell division	38%
what are the broad mechanisms of each?	affects DNA integrity by directly targeting DNA	25%
	cyclophosphamide	25%
	(dihydrofolate reductase (DHFR) inhibitor) that competitively blocks DHFR and blocks DNA synthesis	25%
what are the most important examples of each?	doxorubicin	25%
	membrane modification	25%
	methotrexate	25%
	modification of target site	25%
	other enzyme inhibitors	25%
	prosurvival genes	25%
	(nitrogen mustard alkylating agent) covalently binds to nucleophiles in DNA, blocks DNA replication and interferes with transcription, leading to mutations	13%
	prevents DNA synthesis, as they are structurally similar to metabolites of these enzymes so are mistakenly processed as if they are the metabolites they resemble	13%
why do we use hormones to treat some cancers?	because some cancers are hormone-dependant	0%
	if a cancer cell requires a specific hormone administer an opposing hormone or a hormone antagonist	0%
	inhibit other enzymes	0%
what are the major reasons for the severe side effects of cancer drug therapies?	low therapeutic index	0%