Statistics for Degen Regen References

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General Stats

This quiz has been taken 19 times
The average score is 11 of 37

Answer Stats

Hint	Author	Date	Methods	% Correct
There is very little neuroanatomical or temporal correlation between plaques and degen.	Braak	1991		100%
Greater Abeta42 deposition in ApoE homozygotes; also increased plaque binding (PET)	Castellano		Cognitively normal >70y.o; PET (PIB-radiotracer (plaque))	100%
ChABC increased sprouting (rat sensorimotor cortex), very limited regeneration	Garcia-Alias	2009	(Also Shield 2008)	100%
Alpha synuclein enhances DAT transport to the membrane	Lee	2001	Co-expression of alpha-synuclein, DAT	100%
Parkin mutations, Pink1 mutations decrease number of DAergic neurons in the brain; the expression of parkin rescued both phenotypes	Park	2006	Drosophila	100%
OEC rat thoracic spinal transections	Ramon-Cueto	2003	-	100%
Paralysed man regained some function post OEC transplant	Tabakow	2014	-	100%
LRRK2 is specifically localised in lysosomal-autophagic organelles; knockdown of LRRK2 increases LC-III turnover and autophagy	Wade-Martins	2009	siRNA knockdown	100%
STAT3 selective KO mice	Wanner	2013		100%
Cells overexpressing alpha synuclein have impaired chaperone-mediated autophagy; Rab localisation is massively altered in yeast overexpressing alpha synuclein	Xilouri	2009	-	100%
Rat CST lesion OEC transplant, cells do not pass scar but functional recovery	Yamamoto	2009	high power imaging	100%
Alpha synuclein KO mice have greater vesicle availability	Abeliovich	2000	-	0%
mAb versus ApoE reduced Abeta plaque load in hAPP mice, also recruited microglia	Basak	2012		0%
Induced KO of ApoE in hippocampus reduced insoluble Abeta42 by 50% in hAPP mice	Bien-Ly	2012	KI human ApoEepsilon4 flanked by loxP; Cre recombinase to KO in hippocampus of hAPP mice	0%
Inhibition of lysosomal proteolysis led to accumulation of electron-dense autophagosomes	Boland	2008	Inhibited cysteine proteases	0%
Intrathecal ChABC injections increased fibres crossing a lesion (cats)	Bradbury	2002	-	0%
Ablation of astrocytes in mice increased oedema, leukocyte recruitment, BBB permeability and neuronal loss v WT	Bush	1999	-	0%
Increased VMAT2 when alpha-synuclein is knocked down	Fountaine	2008	in vitro alpha synuclein knockdown	0%
OEC injections dogs w contusive spinal cord injury--> increased hindlimb coordination but no long tract improvement	Granger	2012	-	0%
DJ-1 mutation causes mitochondrial dysfunction, DJ-1 expression can rescue Pink1 mutants	Hao	2010	DJ-1 mutant flies	0%
iPSCs from AD patients can be used to screen drugs, the subsequent neurons had increased Abeta secretion, phosphorylated Tau and activated GSK-3beta	Israel	2012		0%
Abeta oligomers cause neuron death	Jean	2015	Infused Abeta oligomers to hippocampi of mice	0%
ApoE epsilon4 expression increased lysosomal leakage compared to ApoE epsilon3	Ji	2005	ApoE epsilon4 expression in vitro neurons	0%
Alpha synuclein increases mitochondrial fragmentation	Kamp	2010	-	0%
hESC derived DAergic midbrain neurons implanted to mouse PD model, MPTP-lesioned Rhesus monkeys	Kriks	2011	hESCs differentiated to DAergic midbrain neurons	0%
Less acidity of lysosomes in presenelin KO mice	Lee	2010	Immunofluorescent labelling	0%
There is a strong positive correlation between Abeta oligomers and Tau pathology	Lesne	2013	-	0%
Abeta activates NMDARs, which can be partially blocked by subunit antagonism	Li	2011	-	0%
Rho inhibition--> neurite extension to previously inhibitory stripes, CSPG inhibition usually leads to Rho-mediated growth cone collapse	Monnier	2003	-	0%
Antibodies versus TGFbeta1,2 decreases astrocytic response	Moon	2001	GFAP immunohistochemistry	0%
Cells overexpressing alpha synuclein have defective exocytosis	Nemani	2010	pHlourin	0%
Rolipram (PDE IV inhibitor) reduced astrocyte activation, enhanced serotenergic fibre regeneration.	Nikulina	2004	GFAP stain, then 5-HT immunohistochemistry	0%
Accumulation of autophagosomes in neurons from AD brains	Nixon	2005	-	0%
iPSCs succesfully converted from fibroblasts into midbrain neurons	Pfisterer	2011	-	0%
Very little degeneration of Tau KO hippocampal neurons when cultured in Abeta (versus WT)	Rapoport	2002	Tau KO, Abeta culture	0%
Intracerebroventricular injection of Abs versus IL-12,IL-23 (microglial cytokines) decreased amyloid in hAPP mice and improved cognition	Vom Berg	2012	-	0%
Deletion of lysosomal cathepsin inhibitor in hAPP mice decreased e.c. amyloid, giant autolysosomes and caused behavioural improvements	Yang	2011		0%