Hint | Answer | % Correct |
---|---|---|
what are examples of each? | insulin | 100%
|
what are the treatment options for diabetes? | insulin and insulin analogues | 100%
|
what is Type 1 diabetes? | insulin-dependent (absolute deficiency of insulin caused by an autoimmune condition) | 45%
|
insulin secretagogues (sulfonylureas & meglitinides) | 36%
| |
what is the biochemical function of insulin? | to trigger the absorption of glucose from the blood into the liver, skeletal muscle and fat tissue | 36%
|
what are their mechanisms of action? | triggers the absorption of glucose from the blood into the liver, skeletal muscle and fat tissue | 36%
|
improve the response of target cells to insulin by either: - decreasing hepatic gluconeogenesis & reducing intestinal absorption of sugars (biguanides) or: - activation of peroxisome proliferator-activated receptors (thiazolidinediones) | 27%
| |
insulin sensitisers (biguanides & thiazolidinediones) | 27%
| |
what is Type 2 diabetes? | non-insulin-dependent (decreased ability of tissues to respond to normal levels of insulin) | 27%
|
promote insulin release from the b-cells of the pancreas by: - binding to and close ATP-sensitive K+ channels on b-cells - depolarising the cells and opens Ca2+ channels - triggering fusion of insulin granules with cell membrane | 27%
| |
what is the biochemical function of glucagon? | to trigger the release of glucose into the blood from the liver via gluconeogenesis and glycogenolysis | 27%
|
dyslipidaemia | 18%
| |
what are the biochemical features of Type 2 diabetes? | hyperglycaemia | 18%
|
what are the biochemical features of Type 1 diabetes? | hyperglycaemia and ketoacidosis | 18%
|
hypertriacylglycerolaemia | 18%
| |
oral hypoglycemic drugs | 18%
| |
acarbose, miglitol, voglibose | 9%
| |
a-glucosidase inhibitors | 9%
| |
gastrointestinal hormones | 9%
| |
competitively inhibit the action of the enzyme a-glucosidase, that breaks carbohydrates into monosaccharides | 0%
| |
glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), peptide YY (PYY) | 0%
|
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