Unlock Method
|
Achievement
|
Have 7 or more red heart containers at one time
|
Magdalene
|
Hold 55 coins at one time
|
Cain
|
Defeat Satan
|
Judas
|
Defeat Mom
|
The Womb
|
Defeat Mom
|
The Harbingers
|
Defeat Mom
|
A Cube of Meat
|
Defeat a Harbinger
|
The Book of Revelations
|
Defeat Mom's Heart 3 times
|
A Noose
|
Complete Boss Rush as Azazel
|
The Nail
|
Defeat Mom's Heart 8 times
|
A Quarter
|
Defeat Mom's Heart 9 times
|
A Fetus in a Jar
|
Destroy 100 tinted rocks
|
A Small Rock
|
Beat Chapter 1
|
Monstro's Tooth
|
Beat Chapter 2
|
Lil' Chubby
|
Defeat Lokii
|
Loki's Horns
|
Beat Basement 40 times
|
Something From The Future
|
Beat Chapter 2 30 times
|
Something Cute
|
Beat Chapter 3 20 times
|
Something Sticky
|
Pick up Ball of Bandages 4 times in a single run
|
A Bandage
|
Defeat Isaac as Magdalene
|
A Cross
|
Defeat Isaac as Cain
|
A Bag of Pennies
|
Defeat all 7 Deadly SIns
|
The Book of Sin
|
Defeat Gish
|
Little Gish
|
Defeat Steven
|
Little Steven
|
Defeat C.H.A.D.
|
Little C.H.A.D.
|
Enter 10 Arcades
|
A Gamekid
|
Defeat Mom, Mom's Heart, or It Lives! using The Bible
|
A Halo
|
Destroy 10 tinted rocks
|
Mr. Mega
|
Defeat Isaac as ???
|
The D6
|
Die 100 times
|
The Scissors
|
Pick up any 2 items that have the "dead" tag in a single run
|
The Parasite
|
Defeat Mom's Heart 10 times
|
???
|
Defeat Mom's Heart 5 times
|
Everything Is Terrible!!!
|
Defeat Mom's Heart 11 times
|
It Lives!
|
Pick up 3 "Yes Mother?" items in a single run
|
Mom's Contact
|
Use XIII - Death 4 times
|
The Necronomicon
|
Beat Chapter 1 without taking damage
|
Basement Boy
|
Beat Chapter 2 without taking damage
|
Spelunker Boy
|
Beat Chapter 3 without taking damage
|
Dark Boy
|
Beat Chapter 4 without taking damage
|
Mama's Boy
|
Defeat ??? and The Lamb
|
Golden God
|
Don't pick up any hearts for 2 floors in a row
|
Eve
|
Defeat Satan as Isaac
|
Mom's Knife
|
Defeat Satan as Eve
|
The Razor
|
Defeat Satan as Magdalene
|
Guardian Angel
|
Defeat Satan as Cain
|
A Bag of Bombs
|
Defeat The Lamb as Azazel
|
Demon Baby
|
Defeat Satan as ???
|
Forget Me Now
|
Defeat ??? as Isaac
|
The D20
|
Defeat ??? as Magdalene
|
Celtic Cross
|
Defeat The Lamb as Cain
|
Abel
|
Defeat The Lamb as Judas
|
Curved Horn
|
Defeat ??? as Eve
|
Sacrificial Dagger
|
Defeat Isaac as Samson
|
Bloody Lust
|
Defeat ??? as Samson
|
Bloody Penny
|
Defeat Satan as Samson
|
Blood Rights
|
Defeat Isaac 5 times
|
The Polaroid
|
Pick up both key pieces from the Angels in one run
|
Dad's Key
|
Donate 900 coins to the Donation Machine
|
Blue Candle
|
Complete Beans! (Challenge #13)
|
Burnt Penny
|
Destroy 20 Shopkeepers
|
Lucky Toe
|
Complete The Family Man (Challenge #19)
|
Epic Fetus
|
Complete It's in the Cards (Challenge #14)
|
SMB Super Fan
|
Play Shell Game or Hell Game 100 times
|
Counterfeit Coin
|
Become Guppy
|
Guppy's Hairball
|
Pick up 10 Angel Room items
|
A Forgotten Horseman
|
Beat 2 floors in a row without taking damage
|
Samson
|
Defeat Isaac 10 times
|
Something Icky
|
Pick up all non-DLC items and collect all non-DLC secrets and endings (Except The Lost and his 6 unlockable items)
|
!Platinum God!
|
Complete Boss Rush as Isaac
|
Isaac's Head
|
Defeat The Lamb as Magdalene
|
Maggy's Faith
|
Defeat Satan as Judas
|
Judas' Tongue
|
Defeat The Lamb as ???
|
???'s Soul
|
Defeat The Lamb as Samson
|
Samson's Lock
|
Defeat ??? as Cain
|
Cain's Eye
|
Defeat Isaac as Eve
|
Eve's Bird Foot
|
Defeat Ultra Pride or defeat ??? as Judas
|
The Left Hand
|
Defeat Satan 5 times
|
The Negative
|
Take 3 Devil Deals in one run
|
Azazel
|
Have 4 or more soul hearts at one time
|
Lazarus
|
Beat Chapter 4
|
Eden
|
Die in a Sacrifice Room while holding Missing Poster
|
The Lost
|
Beat Chapter 6 without taking damage
|
Dead Boy
|
Pick up all non-DLC items and collect all non-DLC secrets and endings
|
The Real Platinum God
|
Destroy 100 rocks
|
Lucky Rock
|
Beat all Basement bosses (Except Baby Plum)
|
The Cellar
|
Beat all Caves bosses (Except Bumbino)
|
The Catacombs
|
Beat all Depths bosses (Except Reap Creep)
|
The Necropolis
|
Complete Pitch Black (Challenge #1)
|
Rune of Hagalaz
|
Complete High Brow (Challenge #2)
|
Rune of Jera
|
Complete Head Trauma (Challenge #3)
|
Rune of Ehwaz
|
Complete Darkness Falls (Challenge #4)
|
Rune of Dagaz
|
Complete The Tank (Challenge #5)
|
Rune of Ansuz
|
Complete Solar System (Challenge #6)
|
Rune of Perthro
|
Complete Purist (Challenge #20)
|
Rune of Berkano
|
Complete Cat Got Your Tongue (Challenge #8)
|
Rune of Algiz
|
Complete Demo Man (Challenge #9)
|
Chaos Card
|
Complete Cursed! (Challenge #10)
|
Credit Card
|
Complete Glass Cannon (Challenge #11)
|
Rules Card
|
Complete When Life Gives You Lemons (Challenge #12)
|
Card Against Humanity
|
Complete Slow Roll (Challenge #15)
|
Swallowed Penny
|
Complete Computer Savvy (Challenge #16)
|
Robo-Baby 2.0
|
Complete Waka Waka (Challenge #17)
|
Death's Touch
|
Complete The Host (Challenge #18)
|
Tech.5
|
Complete Boss Rush as Lazarus
|
Missing No.
|
Defeat Isaac as Isaac
|
Isaac's Tears
|
Defeat Isaac as Judas
|
Guillotine
|
Complete Boss Rush as Judas
|
Judas' Shadow
|
Complete Boss Rush as Magdalene
|
Maggy's Bow
|
Complete Boss Rush as Cain
|
Cain's Other Eye
|
Defeat The Lamb as Eve
|
Black Lipstick
|
Complete Boss Rush as Eve
|
Eve's Mascara
|
Defeat ??? as ???
|
Fate
|
Complete Boss Rush as ???
|
???'s Only Friend
|
Complete Boss Rush as Samson
|
Samson's Chains
|
Defeat Isaac as Lazarus
|
Lazarus' Rags
|
Defeat Satan as Lazarus
|
Broken Ankh
|
Defeat ??? as Lazarus
|
Store Credit
|
Defeat The Lamb as Lazarus
|
Pandora's Box
|
Complete Suicide King (Challenge #7)
|
Suicide King
|
Defeat Isaac as Eden
|
Blank Card
|
Defeat Satan as Eden
|
Book of Secrets
|
Defeat ??? as Eden
|
Mysterious Paper
|
Defeat The Lamb as Eden
|
Mystery Sack
|
Complete Boss Rush as Eden
|
Undefined
|
Defeat Isaac as Azazel
|
Satanic Bible
|
Defeat Satan as Azazel
|
Daemon's Tail
|
Defeat ??? as Azazel
|
Abaddon
|
Defeat Isaac as The Lost
|
Isaac's Heart
|
Defeat Satan as The Lost
|
The Mind
|
Defeat ??? as The Lost
|
The Body
|
Defeat The Lamb as The Lost
|
The Soul
|
Complete Boss Rush as The Lost
|
The D100
|
Donate 10 coins to the Donation Machine
|
Blue Map
|
Donate 50 coins to the Donation Machine
|
There's Options
|
Donate 150 coins to the Donation Machine
|
Black Candle
|
Donate 500 coins to the Donation Machine
|
Red Candle
|
Donate 999 coins to the Donation Machine
|
Stop Watch
|
Defeat Mom's Heart 4 times
|
Wire Coat Hanger
|
Defeat Mom's Heart 6 times
|
Ipecac
|
Defeat Mom's Heart 7 times
|
Experimental Treatment
|
Pick up 20 Devil Room items
|
Krampus
|
Defeat Krampus
|
Head of Krampus
|
Pick up Cube of Meat 4 times in a single run
|
Super Meat Boy
|
Destroy 100 poops
|
Butter Bean
|
Pick up any 2 items with the "syringe" tag in a single run
|
Little Baggy
|
Use the Blood Donation Machine 30 times
|
Blood Bag
|
Destroy 30 Slot Machines
|
The D4
|
Defeat The Lamb as Isaac
|
Missing Poster
|
Defeat Mom's Heart 2 times
|
Rubber Cement
|
Donate 20 coins to the Donation Machine
|
Store Upgrade lv. 1
|
Donate 100 coins to the Donation Machine
|
Store Upgrade lv. 2
|
Donate 200 coins to the Donation Machine
|
Store Upgrade lv. 3
|
Donate 600 coins to the Donation Machine
|
Store Upgrade lv. 4
|
Beat Chapter 6
|
Angels
|
Earn all Hard mode completion marks as The Lost
|
Godhead
|
Defeat Mom's Heart 11 times and defeat ??? as Eve
|
Darkness Falls
|
Have 7 or more red heart containers at one time
|
The Tank
|
Defeat Mom's Heart 3 times
|
Solar System
|
Defeat Mom's Heart 11 times and unlock Lazarus
|
Suicide King
|
Become Guppy
|
Cat Got Your Tongue
|
Defeat Mom's Heart 9 times
|
Demo Man
|
Have 7 or more red heart containers at one time
|
Cursed!
|
Complete The Family Man (Challenge #19), defeat Lokii, and unlock Judas
|
Glass Cannon
|
Pick up both key pieces from Angels in one run
|
The Family Man
|
Defeat Mom
|
Purist
|
Defeat Mom's Heart or It Lives! on Hard mode as Isaac
|
Lost Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Magdalene
|
Cute baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Eve
|
Crow Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Judas
|
Shadow Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Cain
|
Glass Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Lazarus
|
Wrapped Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Azazel
|
Begotten Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as ???
|
Dead Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as The Lost
|
-0- Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Eden
|
Glitch Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Samson
|
Fighting Baby
|
Become Beelzebub
|
Lord of the Flies
|
Defeat Hush as Isaac
|
Fart Baby
|
Defeat Hush as Magdalene
|
Purity
|
Defeat Hush as Cain
|
D12
|
Defeat Hush as Judas
|
Betrayal
|
Defeat Hush as ???
|
Fate's Reward
|
Defeat Hush as Eve
|
Athame
|
Defeat Hush as Samson
|
Blind Rage
|
Defeat Hush as Azazel
|
Maw of the Void
|
Defeat Hush as Lazarus
|
Empty Vessel
|
Defeat Hush as Eden
|
Eden's Blessing
|
Defeat Hush as The Lost
|
Sworn Protector
|
Defeat Hush as Lilith
|
Incubus
|
Defeat Hush as Keeper
|
Keeper holds Penny
|
Defeat Ultra Greed as Isaac
|
Lil' Chest
|
Defeat Ultra Greed as Magdalene
|
Censer
|
Defeat Ultra Greed as Cain
|
Evil Eye
|
Defeat Ultra Greed as Judas
|
My Shadow
|
Defeat Ultra Greed as ???
|
Cracked Dice
|
Defeat Ultra Greed as Eve
|
Black Feather
|
Defeat Ultra Greed as Samson
|
Lusty Blood
|
Defeat Ultra Greed as Azazel
|
Lilith
|
Defeat Ultra Greed as Lazarus
|
Key Bum
|
Defeat Ultra Greed as Eden
|
GB Bug
|
Defeat Ultra Greed as The Lost
|
Zodiac
|
Defeat Ultra Greed as Lilith
|
Box of Friends
|
Defeat Ultra Greed as Keeper
|
Rib of Greed
|
Defeat Mega Satan as Isaac
|
Cry Baby
|
Defeat Mega Satan as Magdalene
|
Red Baby
|
Defeat Mega Satan as Cain
|
Green Baby
|
Defeat Mega Satan as Judas
|
Brown Baby
|
Defeat Mega Satan as ???
|
Blue Baby
|
Defeat Mega Satan as Eve
|
Lil' Baby
|
Defeat Mega Satan as Samson
|
Rage Baby
|
Defeat Mega Satan as Azazel
|
Black Baby
|
Defeat Mega Satan as Lazarus
|
Long Baby
|
Defeat Mega Satan as Eden
|
Yellow Baby
|
Defeat Mega Satan as The Lost
|
White Baby
|
Defeat Mega Satan as Lilith
|
Big Baby
|
Defeat Mega Satan as Keeper
|
Noose Baby
|
Defeat Isaac as Lilith
|
Rune Bag
|
Defeat ??? as Lilith
|
Cambion Conception
|
Defeat Satan as Lilith
|
Serpent's Kiss
|
Defeat The Lamb as Lilith
|
Succubus
|
Complete Boss Rush as Lilith
|
Immaculate Conception
|
Defeat Mom's Heart or It Lives! on Hard mode as Lilith
|
Goat Head Baby
|
Complete XXXXXXXXL (Challenge #21)
|
Gold Heart
|
Complete SPEED! (Challenge #22)
|
Get out of Jail Free Card
|
Complete Blue Bomber (Challenge #23)
|
Gold Bomb
|
Complete PAY TO PLAY (Challenge #24)
|
2 new pills
|
Complete Have a Heart (Challenge #25)
|
2 new pills
|
Complete I RULE! (Challenge #26)
|
Poker Chip
|
Complete BRAINS! (Challenge #27)
|
Stud Finder
|
Complete PRIDE DAY! (Challenge #28)
|
D8
|
Complete Onan's Streak (Challenge #29)
|
Kidney Stone
|
Complete The Guardian (Challenge #30)
|
Blank Rune
|
Defeat Mom's Heart 10 times
|
Blue Womb
|
Unlock all secrets and endings and pick up every item in Afterbirth
|
1001%
|
Defeat Isaac as Keeper
|
Keeper holds Wooden Nickel
|
Defeat Satan as Keeper
|
Keeper holds Store Key
|
Defeat ??? as Keeper
|
Deep Pockets
|
Defeat The Lamb as Keeper
|
Karma
|
Complete Boss Rush as Keeper
|
Sticky Nickels
|
Defeat Mom's Heart or It Lives! on Hard mode as Keeper
|
Super Greed Baby
|
Donate 2 coins to the Greed Donation Machine
|
Lucky Pennies
|
Donate 14 coins to the Greed Donation Machine
|
Special Hanging Shopkeepers
|
Donate 33 coins to the Greed Donation machine
|
Wooden Nickel
|
Donate 68 coins to the Greed Donation machine
|
Cain holds Paperclip
|
Donate 111 coins to the Greed Donation machine
|
Everything Is Terrible 2!!!
|
Donate 234 coins to the Greed Donation Machine
|
Special Shopkeepers
|
Donate 439 coins to the Greed Donation Machine
|
Eve holds Razor Blade
|
Donate 666 coins to the Greed Donation Machine
|
Store Key
|
Donate 879 coins to the Greed Donation Machine
|
Lost holds Holy Mantle
|
Donate 1000 coins to the Greed Donation Machine
|
Keeper
|
Earn all Hard mode Completion Marks as ???
|
Hive Baby
|
Earn all Hard mode Completion Marks as Isaac
|
Buddy Baby
|
Earn all Hard mode Completion Marks as Magdalene
|
Colorful Baby
|
Earn all Hard mode Completion Marks as Eve
|
Whore Baby
|
Earn all Hard mode Completion Marks as Eden
|
Cracked Baby
|
Earn all Hard mode Completion Marks as Lazarus
|
Dripping Baby
|
Use Blank Card while holding XIX - The Sun
|
Blinding Baby
|
Earn all Hard mode Completion Marks as Azazel
|
Sucky Baby
|
Earn all Hard mode Completion Marks as Lilith
|
Dark Baby
|
Earn all Hard mode Completion Marks as Cain
|
Picky Baby
|
Earn all Hard mode Completion Marks as Samson
|
Revenge Baby
|
Earn all Hard mode Completion Marks as Judas
|
Belial Baby
|
Earn all Hard mode Completion Marks as keeper
|
Sale Baby
|
Defeat Mom
|
XXXXXXXXL
|
Defeat Mom
|
Speed
|
Destroy 10 tinted rocks and defeat Mom's Heart 11 times
|
Blue Bomber
|
Defeat Isaac as Cain and destroy 10 tinted rocks
|
PAY TO PLAY
|
Defeat Mom
|
Have a Heart
|
Defeat Mega Satan and unlock The Negative
|
I RULE!
|
Defeat Isaac 5 times
|
BRAINS!
|
Defeat Mom
|
PRIDE DAY!
|
Unlock Judas and It Lives!
|
Onan's Streak
|
Defeat Mom
|
The Guardian
|
Donate 999 coins to the Greed Donation Machine
|
Generosity
|
Defeat Mega Satan as every character (Except Tainted characters)
|
Mega
|
Defeat Mega Satan and unlock The Negative
|
Backasswards
|
Defeat Mom
|
Aprils Fool
|
Defeat Mom's Heart 11 times
|
Pokey Mans
|
Defeat Mega Satan and unlock The Negative
|
Ultra Hard
|
Defeat Isaac 5 times
|
PONG
|
Defeat Delirium as Isaac
|
D Infinity
|
Defeat Delirium as Magdalene
|
Eucharist
|
Defeat Delirium as Cain
|
Silver Dollar
|
Defeat Delirium as Judas
|
Shade
|
Defeat Delirium as ???
|
King Baby
|
Defeat Delirium as Samson
|
Bloody Crown
|
Defeat Delirium as Eve
|
Dull Razor
|
Defeat Delirium as Eden
|
Eden's Soul
|
Defeat Delirium as Azazel
|
Demon Prince's Crown
|
Defeat Delirium as Lazarus
|
Compound Fracture
|
Defeat Delirium as Lilith
|
Euthanasia
|
Defeat Delirium as The Lost
|
Holy Card
|
Defeat Delirium as Keeper
|
Crooked Penny
|
Defeat Delirium as Apollyon
|
Void
|
Defeat Ultra Greedier as Isaac
|
D1
|
Defeat Ultra Greedier as Magdalene
|
Glyph of Balance
|
Defeat Ultra Greedier as Cain
|
Sack of sacks
|
Defeat Ultra Greedier as Judas
|
Eye of Belial
|
Defeat Ultra Greedier as ???
|
Meconium
|
Defeat Ultra Greedier as Samson
|
Stem Cell
|
Defeat Ultra Greedier as Eve
|
Crow Heart
|
Defeat Ultra Greedier as Eden
|
Metronome
|
Defeat Ultra Greedier as Azazel
|
Bat Wing
|
Defeat Ultra Greedier as Lazarus
|
Plan C
|
Defeat Ultra Greedier as Lilith
|
Duality
|
Defeat Ultra Greedier as The Lost
|
Dad's Lost Coin
|
Defeat Ultra Greedier as Keeper
|
Eye of Greed
|
Defeat Ultra Greedier as Apollyon
|
Black Rune
|
Defeat Isaac as Apollyon
|
Locust of Wrath
|
Defeat Satan as Apollyon
|
Locust of Pestilence
|
Defeat ??? as Apollyon
|
Locust of Famine
|
Defeat The Lamb as Apollyon
|
Locust of Death
|
Complete Boss Rush as Apollyon
|
Locust of Conquest
|
Defeat Hush as Apollyon
|
Hushy
|
Defeat Ultra Greed as Apollyon
|
Brown Nugget
|
Defeat Mega Satan as Apollyon
|
Mort Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Apollyon
|
Smelter
|
Earn all Hard mode Completion Marks as Apollyon
|
Apollyon Baby
|
Defeat Hush
|
New Area
|
Complete a Victory Lap
|
Once More with Feeling!
|
Get a 3-win streak
|
Hat trick!
|
Get a 3-win streak using different characters each time
|
5 Nights at Mom's
|
Collect every entry in the bestiary
|
Sin collector
|
Participate in 31 Daily Challenges (They don't have to be consecutive)
|
Dedication
|
Defeat The Lamb in under 20 minutes
|
ZIP!
|
Defeat The Lamb without picking up hearts, bombs, or keys for the entire run
|
It's the Key
|
Reset 7 times in a row (On Switch/PS4, get a -10 win streak)
|
Mr. Resetter!
|
Beat any Chapter except Chapter 1 on one half heart (Can use The Lost)
|
Living on the edge
|
Pick up 50 items in a run (Can be duplicates)
|
U broke it!
|
Complete Backasswards (Challenge #31)
|
Laz Bleeds More!
|
Complete Aprils Fool (Challenge #32)
|
Maggy Holds a Pill
|
Complete Pokey Mans (Challenge #33)
|
Charged Key
|
Complete Ultra Hard (Challenge #34)
|
Samson Feels Healthy!
|
Complete PONG (Challenge #35)
|
Greed's Gullet
|
Get a 5-win streak in Daily Challenges (They don't have to be consecutive days)
|
The Marathon
|
Complete 3 Victory Laps and start a 4th
|
RERUN
|
Defeat Delirium
|
Delirious
|
Pick up every item in the game, unlock all secrets and endings, complete the Bestiary (Afterbirth+)
|
1000000%
|
Defeat Mega Satan
|
Apollyon
|
Donate 500 coins to the Greed Donation Machine
|
Greedier!
|
Defeat Mom's Heart 11 times
|
Burning Basement
|
Defeat It Lives! 16 times
|
Flooded Caves
|
Defeat It Lives! 21 times
|
Dank Depths
|
Defeat It Lives! 30 times
|
Scarred Womb
|
Defeat ??? as 3 different characters
|
Something wicked this way comes!
|
Defeat ??? as 6 different characters
|
Something wicked this way comes+!
|
Defeat The Lamb
|
The gate is open!
|
Defeat 20 Portals
|
Black Hole
|
Destroy 500 rocks
|
Mystery Gift
|
Beat Chapter 1 without taking damage
|
Sprinkler
|
Become Beelzebub
|
Angry Fly
|
Destroy 5 rainbow poops
|
Bozo
|
Complete 7 Daily Challenges
|
Broken Modem
|
Pick up 5 familiars in a single run
|
Buddy in a Box
|
Defeat Little Horn 20 times
|
Fast Bombs
|
Defeat Delirium for the 1st time
|
Lil Delirium
|
Recharge using Lil' Batteries 20 times
|
Hairpin
|
Sleep in a bed
|
Wooden Cross
|
Complete 2 Victory Laps and start a 3rd
|
Butter!
|
Increase in size 5 times in a single run
|
Huge Growth
|
Use cards or runes 20 times
|
Ancient Recall
|
Pick up both Broken Watch and Stop Watch (Doesn't have to be in a single run)
|
Era Walk
|
Purchase anything from Shops, Devil Rooms, and/or Black Markets 50 times
|
Coupon
|
Beat Chapter 2 without taking damage
|
Telekinesis
|
Use Pandora's Box in Dark Room
|
Moving Box
|
Pick up any 2 items that have the "battery" tag in a single run
|
Jumper Cables
|
Beat Chapter 3 without taking damage
|
Leprosy
|
Pick up any 2 items that have the "tech" tag in a single run
|
Technology Zero
|
Pick up both key pieces in a single run
|
Filigree Feather
|
Open 20 locked chests
|
Mr. ME!
|
Defeat all 5 Harbingers
|
7 Seals
|
Defeat an Angel 10 times
|
Angelic Prism
|
Beat Chapter 4 without taking damage
|
Pop!
|
Destroy doors and Secret Room walls 50 times
|
Door Stop
|
Take 25 Devil Deals
|
Death's List
|
Pick up Blood Clot 10 times
|
Haemolacria
|
Get 10 tear rate upgrades in a single run
|
Lachryphagy
|
Enter 6 Shops in one run
|
Schoolbag
|
Pick up 25 Angel Room items
|
Trisagion
|
Pick up The Battery, 9 Volt, and Car Battery (Doesn't have to be in a single run)
|
Extension Cord
|
Pick up Rubber Cement 5 times
|
Flat Stone
|
Take 50 Devil Deals
|
Sacrificial Altar
|
Die to your own explosion from Ipecac, Bob's Rotten Head, or a Horf! pill
|
Lil Spewer
|
Sleep in 10 beds
|
Blanket
|
Use 5 Gulp! pills in a single run (Can use Placebo)
|
Marbles
|
Spawn 3 charmed enemies in the same room
|
Mystery Egg
|
Have 20 Blue Flies in the same room
|
Rotten Penny
|
Use I - The Magician or Telepathy for Dummies while already having homing tears
|
Baby-Bender
|
It's complicated
|
The Forgotten
|
It's complicated
|
Bone Heart
|
Defeat Mom's Heart or It Lives! on Hard mode as The Forgotten
|
Marrow
|
Defeat Isaac as The Forgotten
|
Slipped Rib
|
Defeat Satan as The Forgotten
|
Pointy Rib
|
Defeat ??? as The Forgotten
|
Jaw Bone
|
Defeat The Lamb as The Forgotten
|
Brittle Bones
|
Complete Boss Rush as The Forgotten
|
Divorce Papers
|
Defeat Hush as The Forgotten
|
Hallowed Ground
|
Defeat Ultra Greed as The Forgotten
|
Finger Bone
|
Defeat Ultra Greedier as The Forgotten
|
Dad's Ring
|
Defeat Delirium as The Forgotten
|
Book of the Dead
|
Earn all Hard mode Completion Marks as The Forgotten
|
Bone Baby
|
Defeat Mega Satan as The Forgotten
|
Bound Soul
|
Defeat Mom's Heart or It Lives! on Hard mode as Lazarus without losing a life
|
Bethany
|
Defeat Mother
|
Jacob and Esau
|
Pick up 3 items with the "stars" item tag in a single run
|
The Planetarium
|
Defeat Hush 3 times
|
A Secret Exit
|
Destroy The Siren's skull after defeating her
|
Forgotten Lullaby
|
Defeat Baby Plum 10 times
|
Fruity Plum
|
Allow Baby Plum to escape instead of defeating her
|
Plum Flute
|
Enter Corpse for the first time
|
Rotten Heart
|
Defeat all bosses in Downpour
|
Dross
|
Defeat all bosses in Mines
|
Ashpit
|
Defeat all bosses in Mausoleum
|
Gehenna
|
Open Mom's Chest in Home
|
Red Key
|
Defeat Mom's Heart or It Lives! on Hard mode as Bethany
|
Wisp Baby
|
Defeat Isaac as Bethany
|
Book of Virtues
|
Defeat Satan as Bethany
|
Urn of Souls
|
Defeat ??? as Bethany
|
Blessed Penny
|
Defeat The Lamb as Bethany
|
Alabaster Box
|
Complete Boss Rush as Bethany
|
Beth's Faith
|
Defeat Ultra Greed as Bethany
|
Soul Locket
|
Defeat Hush as Bethany
|
Divine Intervention
|
Defeat Ultra Greedier as Bethany
|
Vade Retro
|
Defeat Delirium as Bethany
|
Star of Bethlehem
|
Earn all Hard mode Completion Marks as Bethany
|
Hope Baby
|
Defeat Mega Satan as Bethany
|
Glowing Baby
|
Defeat Mom's Heart or It Lives! on Hard mode as Jacob and Esau
|
Double Baby
|
Defeat Isaac as Jacob and Esau
|
The Stairway
|
Defeat Satan as Jacob and Esau
|
Red Stew
|
Defeat ??? as Jacob and Esau
|
Birthright
|
Defeat The Lamb as Jacob and Esau
|
Damocles
|
Complete Boss Rush as Jacob and Esau
|
Rock Bottom
|
Defeat Ultra Greed as Jacob and Esau
|
Inner Child
|
Defeat Hush as Jacob and Esau
|
Vanishing Twin
|
Defeat Ultra Greedier as Jacob and Esau
|
Genesis
|
Defeat Delirium as Jacob and Esau
|
Suplex!
|
Earn all Hard mode Completion Marks as Jacob and Esau
|
Solomon Baby
|
Defeat Mega Satan as Jacob and Esau
|
Illusion Baby
|
Defeat Mother as Isaac
|
Meat Cleaver
|
Defeat The Beast as Isaac
|
Options?
|
Defeat Mother as Magdalene
|
Yuck Heart
|
Defeat The Beast as Magdalene
|
Candy Heart
|
Defeat Mother as Cain
|
Guppy's Eye
|
Defeat The Beast as Cain
|
A Pound of Flesh
|
Defeat Mother as Judas
|
Akeldama
|
Defeat The Beast as Judas
|
Redemption
|
Defeat Mother as ???
|
Eternal D6
|
Defeat The Beast as ???
|
Montezuma's Revenge
|
Defeat Mother as Eve
|
Bird Cage
|
Defeat The Beast as Eve
|
Cracked Orb
|
Defeat Mother as Samson
|
Bloody Gust
|
Defeat The Beast as Samson
|
Empty Heart
|
Defeat Mother as Azazel
|
Devil's Crown
|
Defeat The Beast as Azazel
|
Lil Abaddon
|
Defeat Mother as Lazarus
|
Tinytoma
|
Defeat The Beast as Lazarus
|
Astral Projection
|
Defeat Mother as Eden
|
M
|
Defeat The Beast as Eden
|
Everything Jar
|
Defeat Mother as The Lost
|
Lost Soul
|
Defeat The Beast as The Lost
|
Hungry Soul
|
Defeat Mother as Lilith
|
Blood Puppy
|
Defeat The Beast as Lilith
|
C Section
|
Defeat Mother as Keeper
|
Keeper's Sack
|
Defeat The Beast as Keeper
|
Keeper's Box
|
Defeat Mother as Apollyon
|
Lil Portal
|
Defeat The Beast as Apollyon
|
Worm Friend
|
Defeat Mother as The Forgotten
|
Bone Spur
|
Defeat The Beast as The Forgotten
|
Spirit Shackles
|
Defeat Mother as Bethany
|
Revelation
|
Defeat The Beast as Bethany
|
Jar of Wisps
|
Defeat Mother as Jacob and Esau
|
Magic Skin
|
Defeat The Beast as Jacob and Esau
|
Friend Finder
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Isaac
|
The Broken
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Magdalene
|
The Dauntless
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Cain
|
The Hoarder
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Judas
|
The Deceiver
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as ???
|
The Soiled
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Eve
|
The Curdled
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Samson
|
The Savage
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Azazel
|
The Beknighted
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Lazarus
|
The Enigma
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Eden
|
The Capricious
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as The Lost
|
The Baleful
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Lilith
|
The Harlot
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Keeper
|
The Miser
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Apollyon
|
The Empty
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as The Forgotten
|
The Fettered
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Bethany
|
The Zealot
|
Use the Red Key or Cracked Key to unlock the secret closet in Home as Jacob and Esau
|
The Deserter
|
Defeat The Beast as Tainted Isaac
|
Glitched Crown
|
Defeat The Beast as Tainted Magdalene
|
Belly Jelly
|
Defeat The Beast as Tainted Cain
|
Blue Key
|
Defeat The Beast as Tainted Judas
|
Sanguine Bond
|
Defeat The Beast as Tainted ???
|
The Swarm
|
Defeat The Beast as Tainted Eve
|
Heartbreak
|
Defeat The Beast as Tainted Samson
|
Larynx
|
Defeat The Beast as Tainted Azazel
|
Azazel's Rage
|
Defeat The Beast as Tainted Lazarus
|
Salvation
|
Defeat The Beast as Tainted Eden
|
TMTRAINER
|
Defeat The Beast as Tainted Lost
|
Sacred Orb
|
Defeat The Beast as Tainted Lilith
|
Twisted Pair
|
Defeat The Beast as Tainted Keeper
|
Strawman
|
Defeat The Beast as Tainted Apollyon
|
Echo Chamber
|
Defeat The Beast as Tainted Forgotten
|
Isaac's Tomb
|
Defeat The Beast as Tainted Bethany
|
Vengeful Spirit
|
Defeat The Beast as Tainted Jacob
|
Esau Jr.
|
Unlock Bethany, Blood Bag, and It Lives!
|
Bloody Mary
|
Defeat Satan as Bethany, defeat Mom's Heart 11 times, and unlock Maggy's Faith
|
Baptism by Fire
|
Defeat Mother
|
Isaac's Awakening
|
Defeat Mother
|
Seeing Double
|
Defeat Mom's Heart 11 times and unlock Marbles
|
Pica Run
|
Unlock Tainted Forgotten
|
Hot Potato
|
Unlock Tainted Cain
|
Cantripped!
|
Unlock Tainted Jacob
|
Red Redemption
|
Unlock Tainted Eden
|
DELETE THIS
|
Complete Scat Man (Challenge #36)
|
Dirty Mind
|
Complete Bloody Mary (Challenge #37)
|
Sigil of Baphomet
|
Complete Baptism by Fire (Challenge #38)
|
Purgatory
|
Complete Isaac's Awakening (Challenge #39)
|
Spirit Sword
|
Complete Seeing Double (Challenge #40)
|
Broken Glasses
|
Complete Pica Run (Challenge #41)
|
Ice Cube
|
Donate to Battery Bums until they pay out with an item 5 times
|
Charged Penny
|
Defeat Ultra Greedier as Tainted Lost
|
The Fool?
|
Defeat Ultra Greedier as Tainted Judas
|
The Magician?
|
Defeat Ultra Greedier as Tainted Lilith
|
The High Priestess?
|
Defeat Ultra Greedier as Tainted Eve
|
The Empress?
|
Defeat Ultra Greedier as Tainted ???
|
The Emperor?
|
Defeat Ultra Greedier as Tainted Bethany
|
The Hierophant?
|
Defeat Ultra Greedier as Tainted Magdalene
|
The Lovers?
|
Complete Hot Potato (Challenge #42)
|
The Chariot?
|
Complete Cantripped! (Challenge #43)
|
Justice?
|
Complete Red Redemption (Challenge #44)
|
The Hermit?
|
Defeat Ultra Greedier as Tainted Cain
|
Wheel of Fortune?
|
Defeat Ultra Greedier as Tainted Samson
|
Strength?
|
Defeat Ultra Greedier as Tainted Keeper
|
The Hanged Man?
|
Defeat Ultra Greedier as Tainted Forgotten
|
Death?
|
Complete DELETE THIS (Challenge #45)
|
Temperance?
|
Defeat Ultra Greedier as Tainted Azazel
|
The Devil?
|
Defeat Ultra Greedier as Tainted Apollyon
|
The Tower?
|
Defeat Ultra Greedier as Tainted Isaac
|
The Stars?
|
Defeat Ultra Greedier as Tainted Jacob
|
The Sun?
|
Defeat Ultra Greedier as Tainted Jacob
|
The Moon?
|
Defeat Ultra Greedier as Tainted Lazarus
|
Judgement?
|
Defeat Ultra Greedier as Tainted Eden
|
The World?
|
Destroy 10 Battery Bums
|
Old Capacitor
|
After destroying Hornfel's minecart, kill him before he escapes
|
Brimstone Bombs
|
Earn all Hard mode Completion Marks for all non-Tainted characters)
|
Mega Mush
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Isaac
|
Mom's Lock
|
Defeat Mother as Tainted Isaac
|
Dice Bag
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Magdalene
|
Holy Crown
|
Defeat Mother as Tainted Magdalene
|
Mother's Kiss
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Cain
|
Gilded Key
|
Defeat Mother as Tainted Cain
|
Lucky Sack
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Judas
|
Your Soul
|
Defeat Mother as Tainted Judas
|
Number Magnet
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted ???
|
Dingle Berry
|
Defeat Mother as Tainted ???
|
Ring Cap
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Eve
|
Strange Key
|
Defeat Mother as Tainted Eve
|
Lil Clot
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Samson
|
Temporary Tattoo
|
Defeat Mother as Tainted Samson
|
Swallowed M80
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Azazel
|
Wicked Crown
|
Defeat Mother as Tainted Azazel
|
Azazel's Stump
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Lazarus
|
Torn Pocket
|
Defeat Mother as Tainted Lazarus
|
Torn Card
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Eden
|
Nuh Uh!
|
Defeat Mother as Tainted Eden
|
Modeling Clay
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Lost
|
Kid's Drawing
|
Defeat Mother as Tainted Lost
|
Crystal Key
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Lilith
|
The Twins
|
Defeat Mother as Tainted Lilith
|
Adoption Papers
|
Defeat Isaac, Satan, ???, and Blue Baby as Tainted Keeper
|
Keeper's Bargain
|
Defeat Mother as Tainted Keeper
|
Cursed Penny
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Apollyon
|
Cricket Leg
|
Defeat Mother as Tainted Apollyon
|
Apollyon's Best Friend
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Forgotten
|
Polished Bone
|
Defeat Mother as Tainted Forgotten
|
Hollow Heart
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Bethany
|
Expansion Pack
|
Defeat Mother as Tainted Bethany
|
Beth's Essence
|
Defeat Isaac, Satan, ???, and The Lamb as Tainted Jacob
|
RC Remote
|
Defeat Mother as Tainted Jacob
|
Found Soul
|
Spend 40+ coins in a single Shop
|
Member Card
|
Defeat Delirium as Tainted Isaac
|
Spindown Dice
|
Defeat Delirium as Tainted Magdalene
|
Hypercoagulation
|
Defeat Delirium as Tainted Cain
|
Bag of Crafting
|
Defeat Delirium as Tainted Judas
|
Dark Arts
|
Defeat Delirium as Tainted ???
|
IBS
|
Defeat Delirium as Tainted Eve
|
Sumptorium
|
Defeat Delirium as Tainted Samson
|
Berserk!
|
Defeat Delirium as Tainted Azazel
|
Hemoptysis
|
Defeat Delirium as Tainted Lazarus
|
Flip
|
Defeat Delirium as Tainted Eden
|
Corrupted Data
|
Defeat Delirium as Tainted Lost
|
Ghost Bombs
|
Defeat Delirium as Tainted Lilith
|
Gello
|
Defeat Delirium as Tainted Keeper
|
Keeper's Kin
|
Defeat Delirium as Tainted Apollyon
|
Abyss
|
Defeat Delirium as Tainted Forgotten
|
Decap Attack
|
Defeat Delirium as Tainted Bethany
|
Lemegeton
|
Defeat Delirium as Tainted Jacob
|
Anima Sola
|
Defeat Mega Satan as Tainted Isaac
|
Mega Chest
|
Defeat Mega Satan as Tainted Magdalene
|
Queen of Hearts
|
Defeat Mega Satan as Tainted Cain
|
Gold Pill
|
Defeat Mega Satan as Tainted Judas
|
Black Sack
|
Defeat Mega Satan as Tainted ???
|
Charming Poop
|
Defeat Mega Satan as Tainted Eve
|
Horse Pill
|
Defeat Mega Satan as Tainted Samson
|
Crane Game
|
Defeat Mega Satan as Tainted Azazel
|
Hell Game
|
Defeat Mega Satan as Tainted Lazarus
|
Wooden Chest
|
Defeat Mega Satan as Tainted Eden
|
Wild Card
|
Defeat Mega Satan as Tainted Lost
|
Haunted Chest
|
Defeat Mega Satan as Tainted Lilith
|
Fool's Gold
|
Defeat Mega Satan as Tainted Keeper
|
Golden Penny
|
Defeat Mega Satan as Tainted Apollyon
|
Rotten Beggar
|
Defeat Mega Satan as Tainted Forgotten
|
Golden Battery
|
Defeat Mega Satan as Tainted Bethany
|
Confessional
|
Defeat Mega Satan as Tainted Jacob
|
Golden Trinkets
|
Complete Boss Rush and defeat Hush as Tainted Isaac
|
Soul of Isaac
|
Complete Boss Rush and defeat Hush as Tainted Magdalene
|
Soul of Magdalene
|
Complete Boss Rush and defeat Hush as Tainted Cain
|
Soul of Cain
|
Complete Boss Rush and defeat Hush as Tainted Judas
|
Soul of Judas
|
Complete Boss Rush and defeat Hush as Tainted ???
|
Soul of ???
|
Complete Boss Rush and defeat Hush as Tainted Eve
|
Soul of Eve
|
Complete Boss Rush and defeat Hush as Tainted Samson
|
Soul of Samson
|
Complete Boss Rush and defeat Hush as Tainted Azazel
|
Soul of Azazel
|
Complete Boss Rush and defeat Hush as Tainted Lazarus
|
Soul of Lazarus
|
Complete Boss Rush and defeat Hush as Tainted Eden
|
Soul of Eden
|
Complete Boss Rush and defeat Hush as Tainted Lost
|
Soul of The Lost
|
Complete Boss Rush and defeat Hush as Tainted Keeper
|
Soul of the Keeper
|
Complete Boss Rush and defeat Hush as Tainted Lilith
|
Soul of Lilith
|
Complete Boss Rush and defeat Hush as Tainted Apollyon
|
Soul of Apollyon
|
Complete Boss Rush and defeat Hush as Tainted Forgotten
|
Soul of The Forgotten
|
Complete Boss Rush and defeat Hush as Tainted Bethany
|
Soul of Bethany
|
Complete Boss Rush and defeat Hush as Tainted Jacob
|
Soul of Jacob and Esau
|
Defeat Mother
|
A Strange Door
|
Earn all Hard mode Completion Marks for all characters
|
Death Certificate
|
Unlock every other achievement and pick up every item in the game (Repentance)
|
Dead God
|