Atherosclerosis map (BIO 482)

Name the atherosclerosis steps in order for Dr. Gabriele's class

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Last updated: March 31, 2021

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First submitted	March 31, 2021
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Hint	Answer
1	endothelial cell dysfunction
2	increased permeability to LDLs and adherence of WBCs
3	altered epithelium produces free radicals that oxidize LDLs that accumulate in the intima
4	monocytes invade intima and phagocytose oxidized LDLs forming foam cells

Hint	Answer
5	foam cells and infiltrated T-lymphocytes form fatty streak which later develops into fibrofatty plaque
6	endothelial cells secrete PDGF that stimulate migration of smooth muscle from the media to the intima
7	smooth muscle cells occupying the intima produce a large amount of proteoglycans and collagen that increase the thickness of the intima

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