Embryology - Limb Developement

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Answer

How many weeks into embryological developement do the limb buds arise?

What specific gene/transcription factor denotes where the limb buds form?

What paterning is the Apical Ectodermal ridge involved in?

What chemical does it emit to enable this?

What does the center of the limb bud consist of?

By what week have digits in a healthy individual seperated?

What hormone is responsible for cranial caudal pattterning of the hand?

The area that produces this hormone is referred to as?

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Answer

The process of cartillage turning into bones is referred to as?

By what weel in developement will this start?

Achondroplasia is a disease caused by mutation in the FGF3 receptor, but what is another more colloquial term for it?

Polydactyly is the presence of additional digits and is one of the most common congenital disorders of the upper limb, what is its prevalence? Write in form 1 in 3000 etc.

What drug is known to have caused phocomelia?

Cleidocranial dysplasia is a condition where patients have underdeveloped/no clavicles, what gene is typically associated with it.

The upper limb bud is the first to arise, but where does it derive from?

What type of cells do osteoprogenitor cells differentiate to become?