Statistics for Brain Disorders references

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This quiz has been taken 18 times
The average score is 5 of 30

Answer Stats

hint	author	date	methods	% Correct
MGE neurons electroplated with dominant negative ErbB4 --> largely unresponsive to cortical attractant; ErbB4 mouse mutants have fewer migrating interneurons	Flames	2004	Electroporation, calbindin immunohistochemistry to look at migrating interneurons	100%
alpha versus beta flupenthixol --> only alpha isomer has D2 binding activity and subsequently only alpha isomer has antipsychotic effects	Johnstone	1978	-	100%
Risk of schizophrenia 2.5fold higher if born in Copenhagen versus rural areas	Mortensen	1999	-	100%
Stimulation of VTA in rats upon lever pressing led to addiction	Olds	1954	electrode stimulation	100%
Optogenetic stimulation of DAergic mesolimbic neurons upon lever press--> addiction	Pascoli	2015	ChR2 in mice DAergic mesolimbic neurons--> laser VTA stimulation	100%
Optogenetic stimulation of cortical glutamate neurons increased ventromedial striatal neutron firing and increased OCD-like behaviour	Ahmari	2013	ChR2 in cortical glutamatergic neurons	0%
Increased amygdala activation in patients with PTSD when shown cues	Bremner	1999	PET	0%
Increased glutamine levels in anterior cingulate cortex of schizophrenic patients	Bustillo	2014	-	0%
Amount of current required for action potential significantly greater in shock-resistant cocaine-addicted rats; Photoactivation of ChR2 in prelimbic cortex led to increased PFC activity reducing compulsive cocaine-seeking behaviour	Chen	2013	Whole cell recordings of pyramidal neurons in prelimbic cortex; optogenetic photo activation of prelimbic cortex	0%
gamma2 GABA-A subunit +/- mice had decreased GABA-A receptor function and increased anxiety behaviour	Crestani	1999		0%
Increased DA in NAc upon cue presentation	Day	2007	Pavlovian conditioning using sucrose reward in mice	0%
A GABA-A alpha3 selective agonist had anxiolytic effects without usual side effects	Dias	2005		0%
Persistent increased BDNF expression in VTA, NAc associated with cue-induced cocaine craving tests	Grimm	2003	ELISAs	0%
Individuals with short 5-HTT allele polymorphism had increased amygdala activation	Hairiri	2002	BOLD fMRI	0%
Increased strength of connectivity in anterior orbitofrontal cortex and ventral caudate/NAc in individuals with OCD	Harrison	2009	fMRI	0%
pet1 -/- mice (pet1 important in differentiation of 5-HT neurons) have fewer serotonergic neurons, increased anxiety-like behaviour	Hendricks	2003		0%
Uptake of [18F] DOPA increased in individuals with prodromal symptoms	Howes	2009	PET	0%
Argument that central DA role is to mediate salience: hyperdopaminergia would lead to aberrant assignment of salience	Kapur	2003	-	0%
Decreased NMDAR transmission in hippocampal slices with ErbB4 knockdown	Li	2007	CA3-CA1 pathway: RNAi ErbB4 knockdown	0%
Decreased benzodiazepine site binding in medication-free panic disorder patients	Malizia	1998	PET	0%
Nicotine desensitised nAChRs on GABAergic inputs more than glutamatergic inputs, and so enhances excitation of DAergic neurons	Mansvelder	2002	Rat brain sections with VTA, applied nicotine	0%
Nicotine increased DA release during high-frequency firing patterns, more than low-frequency--> high-freq. associated with reward	Rice	2004	Guinea pig NAc, cholinergic inputs desensitised with nicotine	0%
Increased dendritic length, decreased spine density in PFC, NAc of amphetamine-treated rats	Robinson	1997	-	0%
Greater DAergic VTA firing if the reward is higher than expected, leading to positive reinforcement and greater firing next time cue is presented; vice versa	Schultz	1997	Monkeys reward association task	0%
Positive correlation between the potency of antipsychotics and D2 binding	Seeman	1976	-	0%
Decreased DA release in dorsolateral PFC of schizophrenic patients although not associated with negative symptoms	Slifstein	2015	PET--> amphetamine induced DA release in dorsolateral PFC	0%
LTD contributes to prefrontal-stratal hyperactivity in addiction	Thomas	2001	-	0%
Place paradigm using optogenetics--> mice showed preference for chamber with VTA stimulation	Tsai	2009	Same optogenetics as Pascoli	0%
Increased D2 PET signal in dorsal striatum of cocaine addicts shown scenes of drug purchase/preparation	Volkow	2005	PET in dorsal striatum using 11[C] raclopride	0%
5-HT2AR -/- mice had decreased anxiety-like behaviour	Weisstaub	2006		0%