|
Hint
|
Author
|
Year
|
Methods
|
|
Deep-to-superficial migration of radial glial cells
|
Angevine
|
1961
|
3[H]-thymidine injected at progressive stages during pregnancy (mice)- labelled progressively more superficial layers
|
|
Mutated reelin (Reeler mice) have inverted cortices
|
Falconer
|
1951
|
|
|
CPN migration is nearly all radial
|
Tan
|
1995
|
Female mice homozygous for LacZ on X chromosome; random X inactivation- beta galactosidase staining showed radial stripes
|
|
Clonally related interneurons found in cortical and subcortical areas separated by long distances
|
Mayer
|
2015
|
Retrovirus expressing unique DNA barcodes as label
|
|
Retrovirus injections with eGFP to MGE progeny showed clustering of interneurons in cortex
|
Brown
|
2011
|
|
|
Decreased density of GAD67 (interneuron marker) seen in schizophrenia
|
Volk
|
2000
|
In situ hybridisation of tissue sections from schizophrenia patients
|
|
CNTNAP2 KO mice have no gross abnormalities but ectopic neurons in corpus callosum; reduced number of cortical interneurons and mice showed autism-like behaviorus
|
Peñagarikana
|
2010
|
GAD1 staining (interneuron marker)
|
|
Neurite outgrowth increased in laminin, fibronectin compared with collagen IV alone
|
Gundersen
|
1987
|
Chick DRG neurons cultured in these media; stripes of laminin
|
|
All axons grew towards NGF source, sensitive to extremely low concentration
|
Gundersen
|
1979
|
|
|
As above but with fluorescent markers
|
Paves
|
1997
|
|
|
Neurons turn away after making filopodial contact with semaphoring III beads
|
Fan
|
1995
|
|
|
Netrin1/DCC double KO mice have optic nerve hypoplasia
|
Deiner
|
1997
|
|
|
Severed newt optic nerves, rotated eye 180degrees; recovered vision, RGCs made contact with original tectal targets
|
Sperry
|
1943
|
|
|
Severed goldfish optic nerve, removed temporal retina; nasal axons regenerated to tectal targets
|
Sperry
|
1963
|
|
|
Protease treatment abolished pattern by which temporal neurons usually avoid areas with caudal tectum membrane
|
Bahnhöffer
|
1987
|
|
|
Complimentary tectal, retinal gradients of ephrinA2; EphA3
|
Cheng
|
1995
|
In situ hybridisation, chicks
|
|
EphA5 -/- mice; temporal RGCs were labelled in the caudal SC (only nasal in WT)
|
Frisen
|
1995
|
anterograde/retrograde staining
|
|
Selective Pals1 KO led to premature withdrawal of radial glia from cell cycle and severe cortical malformation
|
Kim
|
2010
|
|
|
Intermediate progenitors derive from radial glia, produce neurons
|
Noctor
|
2004
|
GFP labelling
|
|
Selective Tbr2 inactivation in mice caused selective deficits in SVZ progenitors
|
Arnold
|
2008
|
Sox1-Cre KO; in situ hybridisation
|
|
Tbr2 mutations in humans cause microcephaly, polymicrogyria and corpus callosum agenesis
|
Baala
|
2006
|
|
|
Transplant of labelled progenitor cells from E31 ferrets which normally form layer V/VI to proliferative zone of newborn ferrets where they would normally form layer II/III; saw 50:50 distribution
|
McConnell
|
1988
|
|
|
Cux2 is selectively expressed in upper cortical layers, but is seen in the cells of the VZ in mice at the earliest stage of neurogenesis (E14.5)
|
Franco
|
2012
|
In situ hybridisation
|
|
Fezf2 over expression altered CCPN projection patterns to more closely resemble CFuPN patterns
|
Chen
|
2008
|
|
|
CCPNs in SatB2 mutants are absent from corpus callosum, project through the internal capsule (CFuPN fate)
|
Alcamo
|
2008
|
Mice expressing LacZ from SatB2 locus
|
|
Early Nkx2.1 removal led to gross deficit in cortical interneurons
|
Butt
|
2008
|
|
