|
anemia
|
|
frontal bossing
|
thalassemia
|
|
thalassemia MC in east asians
|
alpha thalassemia
|
|
target cells
|
thalassemia
|
|
howell jolly bodies
|
sickle cell anemia
|
|
heinz bodies (2)
|
alpha thalassemia, G6PD deficiency
|
|
hydrops fetalis
|
thalassemia
|
|
thalassemia MC in meditteraneans
|
beta thalassemia
|
|
dactylitis
|
sickle cell anemia
|
|
pica, pagophagia, koilonychia
|
iron deficiency anemia
|
|
elevated methylmalonic acid
|
vitamin B12 deficiency
|
|
vasocclusive crisis
|
sickle cell anemia
|
|
paresthesias, gait abnormalities, memory loss
|
vitamin B12 deficiency
|
|
increased hepcidin and ferritin, decreased serum iron and TIBC
|
anemia of chronic disease
|
|
HFE protein mutation
|
hemochromatosis
|
|
absorbed in the terminal ileum
|
vitamin B12 deficiency
|
|
valine substitution for glutamic acid on beta chain
|
sickle cell anemia
|
|
elevated homocysteine (2)
|
vitamin B12 and B9 deficiency
|
|
episodic hemolytic anemia
|
G6PD deficiency
|
|
positive schilling test
|
vitamin B12 deficiency
|
|
MCC of vitamin B12 deficiency
|
pernicious anemia
|
|
autoimmune destruction of intrinsic-factor producing parietal cells
|
pernicious anemia
|
|
hypersegmented neutrophils, macroovalocytes (2)
|
vitamin B12 and B9 deficiency
|
|
schistocytes (bite cells) (2)
|
G6PD deficiency, TTP
|
|
x-linked disorder (3)
|
G6PD deficiency, hemophilia A, hemophilia B
|
|
fava beans, dapsone, primaquine
|
G6PD deficiency
|
|
absorbed in jejunum
|
folic acid deficiency
|
|
decreased hepcidin, increased hemosiderin
|
hemochromatosis
|
|
jaundice
|
G6PD deficiency
|
|
bronze skin, DM, cardiomyopathy, hypogonadism, erectile dysfunction
|
hemochromatosis
|
|
|
thrombocytopenia
|
|
ADAMSTS1 antibody
|
TTP
|
|
post-viral infection
|
TTP
|
|
isolated PLT defect
|
TTP
|
|
mucocutaneous bleeding, petechiae
|
von willebrand's disease
|
|
fever, microangiopathic hemolytic anemia, thrombocytopenia, renal failure, neurological changes
|
TTP
|
|
MC inherited clotting disorder
|
von willebrand's disease
|
|
normal coagulation studies (2)
|
Factor V Leiden, TTP
|
|
elevated d-dimer
|
DIC
|
|
prolonged PTT (3)
|
von willebrand's disease, hemophilia A, hemophilia B
|
|
decreased haptoglobulin
|
TTP
|
|
GP IIb/IIa receptor antibody
|
ITP
|
|
mucocutaneous bleeding, purpura, petechiae, gingival bleeding
|
ITP
|
|
dripping blood
|
DIC
|
|
|
|
|
polycytosis
|
|
JAK2 mutation
|
polycythemia vera
|
|
hyperviscous blood, increased hgb
|
polycythemia vera
|
|
facial plethora
|
polycythemia vera
|
|
pruritus after hot bath/shower (2)
|
polycythemia vera, CML
|
|
|
|
|
thrombophilia
|
|
vitamin K dependent protein deficiency
|
protein C deficiency
|
|
thrombosis, miscarriage
|
factor v leiden
|
|
warfarin-induced skin necrosis
|
protein C deficiency
|
|
purpura fulminans, thrombosis
|
protein C deficiency
|
|
|
hemophilia
|
|
hemarthrosis
|
hemophilia
|
|
factor 8 deficiency
|
hemophilia A
|
|
factor 9 deficiency
|
hemophilia B
|
|
christmas disease
|
hemophilia B
|
|
|
|
|
blood disorder
|
|
autosomal dominant disorder (2)
|
von willebrand's disease, protein c deficiency
|
|
autosomal recessive disorder (3)
|
hemochromatosis, hemophilia A, hemophilia B
|
|
|
|
|
leukemia
|
|
auer rods
|
AML
|
|
MC childhood malignancy
|
ALL
|
|
pancytopenia (3)
|
AML, ALL, CLL
|
|
leukemia cutis
|
CLL
|
|
smudge cells
|
CLL
|
|
hypercellular bone marrow w/ > 20% blasts
|
ALL
|
|
overproliferation of mature lymphocytes
|
CLL
|
|
overproliferation of immature WBC blasts (2)
|
AML, ALL
|
|
9-22 chromosomal translocation
|
CML
|
|
philadelphia chromosome
|
CML
|
|
overproliferation of mature granulocytes
|
CML
|
|
nontender, round and freely mobile, cervical/supraclavicular LAD
|
CLL
|
|
treated w/ tyrosine kinase inhibitors
|
CML
|
|
|
lymphoma
|
painless cervical/supraclavicular LAD (firm, nontender, freely mobile) |
Hodgkins lymphoma
|
|
painful LAD after alcohol consumption
|
Hodgkins lymphoma
|
|
mandibular/maxillary mass
|
burkitt's lymphoma
|
|
painless peripheral LAD
|
non Hodgkins lymphoma
|
|
contiguous spread through upper body LN
|
Hodgkins lymphoma
|
|
associated w/ EBV
|
Hodgkins lymphoma
|
|
extranodal spread to GI tract
|
non Hodgkins lymphoma
|
|
diffuse B cell MC type
|
non Hodgkins lymphoma
|
|
pel-ebstein (cyclical) fever
|
Hodgkins lymphoma
|
|
EBV endemic to South Africa
|
burkitt's lymphoma
|
|
nodular sclerosis MC type
|
Hodgkins lymphoma
|
|
reed sternburg cells (bilobular nucleus)
|
Hodgkins lymphoma
|
|
starry sky appearance on histology
|
burkitt's lymphoma
|
|
aggressive subtype of nonhodkins lymphoma
|
burkitt's lymphoma
|
|
|
|
|
myeloma
|
|
bence jones proteins
|
multiple myeloma
|
|
bone pain (spine/rib), recurrent infection, elevated calcium, anemia, kidney failure
|
multiple myeloma
|
|
roleaux formation
|
multiple myeloma
|
|
preleukemic disorder that may progress to AML
|
myelodysplasia
|
|
plasmacytosis > 10% on bone marrow biopsy
|
multiple myeloma
|
|
punched out lytic lesions on skull XRAY
|
multiple myeloma
|
|
increased monoclonal Ab
|
multiple myeloma
|
|
> 20% myeloblasts on bone marrow biopsy
|
myelodysplasia
|
|
