Statistics for antiviral drugs

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General Stats
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General Stats

This quiz has been taken 7 times
The average score is 39 of 51

Answer Stats

Hint	Answer	% Correct
	airborne or droplet transmission	100%
what is influenza?	an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae	100%
	blocks the virus from uncoating within the cell	100%
	direct contact	100%
what are the 3 types of viruses?	DNA viruses	100%
	fecal-oral transmission	100%
	human immunodeficiency virus (HIV) 1 and 2, human T-lymphotropic viruses (HTLV)	100%
	indirect contact	100%
	inhibit replication or reverse transcription	100%
	integrase inhibitors	100%
what are their mechanisms of action?	it is an antiretroviral integrase inhibitor, and works by blocking the integrase enzyme needed to allow the viral DNA to integrate into the host genome, meaning the retrovirus cannot replicate	100%
what drug type is most commonly used to treat influenza?	neuraminidase inhibitors	100%
	neuraminidase inhibitors	100%
what is an example of each?	poxviruses (e.g. smallpox), herpesviruses (e.g. shingles), papillomaviruses (e.g. HPV)	100%
	protease inhibitors	100%
	retroviruses	100%
	rhinoviruses (e.g. common cold), coronaviruses (e.g. Sars- CoV-2), influenza, rabies, measles	100%
	RNA viruses	100%
	uncoating	100%
	uncoating inhibitors	100%
	uses protease to stop the virus from being release from the cell	100%
what are the forms of viral transmission?	vector transmission	100%
	vertical transmission	100%
what are the main types of antiviral drugs?	attachment inhibitors	80%
	blocks retroviruses from being able to perform reverse transcription	80%
	entry inhibitors	80%
	genome is comprised of RNA, but the virus converts this back into DNA and inserts a DNA copy of its genome into the host genome	80%
	genome replication	80%
	is a nucleotide reverse transcriptase inhibitor whose active metabolite blocks the reverse transcription of HIV RNA into DNA	80%
	it is a nucleoside reverse transcriptase inhibitor whose active metabolite blocks the reverse transcription of HIV RNA into DNA	80%
what are the targets for antiviral drugs?	proteins that can be inhibited, particularly proteins that are conserved across species (and are dissimilar to human proteins)	80%
how do human immunodeficiency viruses (HIV) replicate?	they are retroviruses, so they reverse transcribe their RNA genome into DNA, and insert it into the host cell genome	80%
how do we use it to treat HIV?	administer a combination of 3 antiviral drugs (typically 1 non-nucleoside reverse transcriptase inhibitor and 2 nucleoside reverse transcriptase inhibitors, plus an integrase inhibitor)	60%
	blocks the virion particles from being release from the cell	60%
what are the drugs used in this treatment?	dolutegravir	60%
	expression of virus genome translation/transcription	60%
what is the frontline treatment option for HIV?	highly active antiretroviral therapy (HAART)	60%
	lamivudine	60%
	polymerase inhibitors	60%
	release of virions	60%
	tenofovir disoproxil	60%
how does it treat influenza?	their active metabolites competitively inhibit influenza virus neuraminidase enzymes, which stops influenza virions from being released from the cell	60%
how do they replicate?	using DNA polymerase	60%
	assembly	40%
what is the basic viral replication cycle?	virus adsorbtion	40%
	virus penetration	40%
	blocks the virus from fusing to the cell membrane	20%
	protein synthesis	20%
	reverse transcriptase inhibitors	20%
what are their mechanisms of action?	the drug will bind where the virus attaches, blocking the virus from binding	20%
	blocks the virus from integrating with the host DNA	0%