Pharmacology of Peripheral Neural Transmission

Important Drugs from Dr Taufiq Rahman's Lecture Series 22/23

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Last updated: May 15, 2023

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Hint		Answer
Inhibit ChT	Rate limiting for ACh Synthesis	Hemicholinium
Inhibit VAChT		Vesamicol
Nn Agonist	Desensitise at high conc.	Nicotine
Nn Agonist	Quit smoking	Varenicline
Nn Anatagonist		Trimethaphan
Nn Antagonist		Hexamethonium
Depolarising Nm Antagonist	degraded by pseudoAChE Phase I fasciculations Phase II Desensitisation Hyperkalaemia	Suxamethonium
Non-depolarising Nm Antagonist		Curare
Non-depolarising Nm Antagonist	Aminosteroid	Rocuronium
Non-depolarising Nm Antagonist	Benzylisoquinolinium	Atracurium
mAChR Agonist	Stim Detrusor M3	Bethanechol
mAChR Agonist	Glaucoma, accomodation spasm	Pilocarpine
mAChR Antagonist	M2 in SAN	Atropine
mAChR Antagonist	M3 COPD	Ipatropium
mAChR Antagonist	M3 Incontinence	Solifenacin
AntiCholinesterase	Blocks CAS, diagnose Myasthenia	Edrophonium
AntiCholinesterase	Carbamylates Ser	Neostigmine
AntiCholineseterase	Phosphorylates Ser	Organophosphates
Treat Sarin		Pralidoxime
Inhibits VMAT2	Causes depression, antihypertensive	Reserpine
Competes for TOH	Treat Phaeochromocytoma	aMethylTyrosine
False Transmitter production		aMethylDOPA
Inhibits DDC	Peripheral only	Carbidopa
Block catecholamine release	Accumulates via NET/VMAT2	Guanethidine
Indirect Sympathomimetic	Cheese Effect	Tyramine

Hint		Answer
Indirect Sympathomimetic	Treat Narcolepsy	Dexamfetamine
Mixed Sympathomimetic	Bronchodilation + nasal vasoconstriction (Decongestant)	Ephedrine
Block NET		Cocaine
Block NET		Imipramine
Block ENT		Corticosteroids
COMT inhibitor	+ Carbidopa + aMethylDOPA vs Parkinsons	Entacapone
Non-selective AR Agonist	Anaphylaxis	Adrenaline
a AR Agonist		Xylometazoline
a AR Agonist		Noradrenaline
a1 AR Agonist	Nasal Decongestant	Phenylephrine
a2 AR Agonist	Hypotensive Agent via decrease NT Release	Clonidine
a2 AR Agonist		aMethylDOPA
b AR Agonist	Asthma but high HR	Isoprenaline
b1 AR Agonist	Cardiogenic Shock but causes dysrythmia	Dobutamine
b2 AR Agonist	Asthma	Salbutamol
b2 AR Agonist	COPD	Salmeterol
b3 AR Agonist	Relaxes Bladder	Mirabegron
a AR Antagonist	Hypotensive	Phenoxybenzamine
a1 AR Antagonist	↓ TPR, ↓ BP, incontinence	Prazosin
a1 AR Antagonist	Relaxes prostate ↓ hypertrophy	Tamulosin
a2 AR Antagonist		Yohimbine
b AR Antagonist	↓CO, but ↓ renin + ↓TPR	Propranolol
b1 AR Antagonist	↓CO	Atenolol
b1 AR Antagonist	↓CO + NO Release	Nebivolol
ATP Antagonist		Suramin

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