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Paper 2 references

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Quiz by mz
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Last updated: May 24, 2018
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First submittedMay 24, 2018
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Author
Date
Methods
Selective TDP-43 depletion in post mitotic motor neurons-- ALS like phenotype
Wu
2012
One TDP-43 allele KOd, the other floxed; Cre recombinase expressed under HB9 promoter.
Overexpression of TDP-43 caused clear aggregates and loss of upper and lower MNs
Wils
2010
 
Discovered first clock gene- "per", since "per" null flies were arrhythmic, flies with missense mutations had altered circadian rhythms
Benzer
1971
Screened mutant drosophila (A further clock gene- "cry" was identified soon after with similar strategy).
Mice with double mPer1/ mPer2 KO have no intrinsic circadian rhythms
Zheng
2010
 
D1 optic stimulation - increased movement (direct pathway); D2 optic stimulation- decreased movement (Indirect pathway)
Kravitz
2010
 
Decreased D2 receptor occupancy in people with schizophrenia
Abi-Dargham
2000
SPECT
Confirmation of Schultz 1999 - mice sucrose reward (prediction-error model)
Day
2007
Fast-scan voltammetry (FCV)
Mapped somatotopic hand area in S1 in individuals with syndactyly - showed shrunken, ill-defined cortical organisation
Mogilner
1983
 
Auditory-evoked MEG responses to human voices in schizophrenia patients - showed significant auditory gating deficits
Hirano
2010
 
X-irradiated rats during main stage of oligodendrocyte proliferation - almost no staining for MBP and increased number of optic nerve fibres
Colello
1994
 
Nogo-A KO mice; CST transections - increased labelled fibres found crossing the lesion indicating enhanced regen.
Simonen
2003
Anterograde labelling
Nogo-A,B,C triple KO mice; dorsal hemisection of spinal cord - no significant difference in axon regen.
Lee
2009
Anterograde labelling
NgR mutant mice had no significant difference in regenerative response to spinal cord injury
Zheng
2005
 
OMgp -/- mice; complete spinal cord transections - increased labelled axons rostral to lesion although limited and no regen in CST
Ji
2008
 
ephrinB3 -/- mice; CST fibres labelled following dorsal hemisection; after 6 weeks - large number of fibres entering lesion site (none in WT)
Duffy
2012
 
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