Statistics for neurodegenerative disease drugs

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This quiz has been taken 8 times
The average score is 23 of 34

Answer Stats

Hint	Answer	% Correct
what are the 3 distinguishing features of Alzheimer's disease?	accumulation of senile plaques (b-amyloid accumulations)	100%
	formation of numerous neurofibrillary tangles	100%
what is Parkinson's disease characterised by?	insidious onset, with slowing of voluntary movement, muscular rigidity, postural abnormality & tremors	100%
what are the drugs used to treat Alzheimer's disease?	acetylcholinesterase inhibitors	83%
	allosterically binding to GABAA receptors on post- synaptic neurons	83%
	amantadine	83%
what is an example of a motor neuron disease?	amyotrophic lateral sclerosis (ALS) etc	83%
	carbidopa	83%
what is an example of each?	donepezil, rivastigmine, etc	83%
what drugs do we use to treat Parkinson's?	dopamine precursors	83%
	dopamine receptor agonists	83%
what are examples of each?	levodopa	83%
	loss of cortical neurons (especially cholinergic neurons)	83%
what are the physical effects of motor neuron disease?	loss of motor neurons and muscle control until the patient can no longer eat, speak, move or breathe, with respiratory failure being the usual cause of death	83%
	memantine	83%
what is the mechanism of action of each?	metabolic precursor of dopamine, that is converted to dopamine by aromatic L-amino acid decarboxylase (AADC)	83%
	benzatropine	67%
what are the mechanisms of action of the first drug thought to be?	binding to glutamate receptors to reduce the release of glutamate	67%
	inhibitors of dopamine metabolism	67%
	NMDA receptor antagonists	67%
	preferentially blocking TTX-sensitive sodium channels, which are linked to neuronal damage	67%
what are the drugs indicated specifically for motor neuron disease?	riluzole, baclofen, edaravone, tizanidine	67%
what is Parkinson's disease caused by?	the striatal deficiency of dopamine following neuronal degeneration within the substantia nigra	67%
	uncompetitive antagonists at glutamatergic NMDA receptors	67%
what is motor neuron disease?	a group of related neurodegenerative diseases that affect motor neurons and therefore voluntary muscle control	50%
	antimuscarinic drugs	50%
	bromocriptine, pramipexole, etc	50%
what is the mechanism of action of each?	preferentially inhibits acetylcholinesterase (AchE) in the CNS over peripheral enzymes	50%
what does pharmacological treatment aim to do for Parkinson's?	restore dopamine levels in basal ganglia	50%
	inhibits AADC in peripheral tissues to increase availability of levodopa in the CNS by allowing more to cross the BBB before being converted to dopamine	33%
	selectively blocks activity at the M1 muscarinic acetylcholine receptor, reducing cholinergic activity in the basal ganglia and restoring the ‘balance’ of acetylcholine and dopamine	33%
	unknown, but thought to weakly inhibit the NMDA and nicotine receptors, as well as activate dopamine receptors	17%
	agonists at dopamine D2 receptors, working to restore dopamine signalling in the striatum	0%
	reduce the excitatory effect of acetylcholine	0%