Statistics for respiratory drugs

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General Stats

This quiz has been taken 9 times
The average score is 31 of 44

Answer Stats

Hint	Answer	% Correct
what is the one anticholinergic drug used in Australia to treat asthma?	ipratropium	100%
	ipratropium	100%
what are the nasal decongestants used to treat allergic rhinitis?	phenylephrine	100%
	pseudoephedrine	100%
what are the types of antihistamines used to treat allergic rhinitis?	1st generation	75%
	2nd generation	75%
	act on central H1 receptors	75%
what is omalizumab used to treat?	allergic asthma	75%
	allergic rhinitis	75%
what kind of molecule is omalizumab?	a recombinant-derived monoclonal antibody	75%
what is the mechanism of action of each of these?	blocks the generation of leukotrienes from arachidonic acid by inhibiting 5-lipoxygenase	75%
	codeine	75%
	corticosteroids	75%
what are the drugs that treat cough?	dextromethorphan	75%
what is an example of a corticosteroid used to treat asthma?	fluticasone, prednisolone, etc	75%
what is its mechanism of action?	it binds to immunoglobulin E (IgE) and reduces binding of IgE to its receptor on the surface of basophils, mast cells and dendritic cells	75%
what does this do to mast cells?	it limits the degranulation of mast cells, thereby reducing release of pro-inflammatory mediators involved in the allergic response	75%
	long acting	75%
	loratadine, fexophenadine, etc	75%
what kind of drugs are cromolyn & nedocromil?	mast cell stabilisers	75%
	monteleukast, zafirleukast, & pranleukast	75%
	pholcodine	75%
what is their mechanism of action?	phosphodiesterase inhibitors: competitive enzyme inhibition results in sustained elevation of cAMP or cGMP resulting in bronchodilation	75%
what do they do?	prevent the release of inflammatory mediators such as histamine	75%
what is an example of each?	salbutamol, terbutaline, etc	75%
	salmetrol, bambuterol, etc	75%
what receptors do they act on?	selective for peripheral H1 receptors	75%
what are the 3 types of sympathomimetics used to treat asthma?	short acting	75%
what is an example?	theophylline, aminophylline	75%
what is their mechanism of action?	they act on peripheral H1 histamine receptors (in mast cells, endothelium and smooth muscle) to reduce the symptoms of allergic rhinitis	75%
what is their mechanism of action?	they are a1-adrenergic receptor agonists that cause vasoconstriction and increase mucociliary clearance, therefore decreasing airway resistance	75%
	thought to activate μ and k opioid receptors in the cough centre of the brain	75%
	thought to activate μ and k opioid receptors in the cough centre of the brain	75%
what are the leukotriene antagonists used to treat asthma?	zileuton	75%
what is their mechanism of action?	activation of b2 receptors relaxes smooth muscle in the airways (bronchodilation), without affecting inflammation	50%
what drugs are used to treat COPD?	b-adrenergic agonists	50%
what are their postulated mechanisms of action?	binds to sigma receptors in the cough centre of the brain	50%
	carmoterol, indacaterol, etc	50%
what is an example of these?	chlorphenamine, mepyramine, etc	50%
what kind of drugs are xanthines?	naturally occurring stimulants	50%
what is their mechanism of action?	they bind to the glucocorticoid receptor to up-regulate expression of several anti-inflammatory proteins as well as down-regulate pro-inflammatory proteins	50%
	they inhibit cysteinyl leukotriene receptor 1 (cysLT1), blocking the action of leukotriene D4	50%
what is its mechanism of action?	works as a non-selective muscarinic receptor antagonist to: - decrease Ach-mediated bronchospasms - reduce irritant-induced mucus secretion - increase ciliary clearance	50%
	ultra long acting	25%