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Inflammation 4
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MedSoc
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Last updated: December 20, 2018
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First submitted
December 20, 2018
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Answer
What type of molecule, with P and E variants arises on endothelial cells surfaces to bind the Sialyl-Lewis bodies on neutrophils?
Selectin
There are two molecules envolved in tight adhesion integrins (LFA-1) from the neutrophil and what Ig superfamily molecule from the endothelium?
ICAM
What is the name givento the process of neutrophils squeezing between the gaps between endothelial cells?
Diapedesis/extravasation
What enzyme does the neutrophil secret to degrade the basement membrane?
Elastase
What rare immunological disease is caused by a defect in the recruitment of neutrophils. Specifically a mutation in CD18.
LAD/ leukocyte Adhesion Disease
What is the main cytokine that induces septic shock?
TNF alpha
This cytokine may also cause blood clotting in small vessels throughout the body, what is the referred to as?
Disseminated intravascular coagulation
Whst is the name gien to the tissue that appears after cell damage, which is attempting to replace dead tissue with healthy cells?
Granulation
What cell is known as the central cell controlling the repair process?
Macrophage
What do they release in order to recruit new endothelial cells?
VEGF/ Vascular Endothelial Growth Factor
What is the term given to the formation of new blood vessels?
Angiogenesis
What small spherical structure of cells may be caused in chronic inflammation?
Granuloma
When the centre of this sphere necroses it forms a white substance similar to cheese, this has lead to it being referred to as what type of necrosis?
Caseous
What 'large' cell may be found in the centre of one of them?
Multi-nucleated giant
What cells are found around the edge?
T cell
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