|
Hint
|
Author
|
Year
|
Methods
|
|
Specific cells fired maximally when mouse is in specific parts of the environment
|
O'Keefe
|
1971
|
|
|
NMDAR-dependent LTP is required for associative spatial memory acquisition
|
Morris
|
1986
|
Mice, NMDAR antagonists
|
|
Spatial pre-training in another maze ameliorated effects of above experiment
|
Bannerman
|
1995
|
|
|
Decreased performance in a Morris water maze when LTP could not be induced, due to hippocampus-selective GluN1 KO
|
Tsien
|
1996
|
|
|
GluA1 -/- mice have large reductions in measures of spatial and directional selectivity
|
Resnik
|
2012
|
Radial maze--> decreased peformance
|
|
A peptide preventing AMPAR internalisation blocked LTD induction and led to deficits in object recognition in rats
|
Griffiths
|
2008
|
|
|
Selective destruction of climbing fibres abolished NO responses
|
Shibuki
|
1991
|
NO probe
|
|
Purkinje-specific PKG KO in mice led to inability to induce LTD and impaired VOR adaptation
|
Feil
|
2003
|
|
|
PKC inhibitor expressed under Purkinje-specific promoter in transgenic mice--> attenuated LTD, VOR adaptation impaired
|
De Zeeuw
|
1998
|
|
|
Attenuated LTD by perfusing Purkinje cells with peptides interfering with PICK1/GluR interactions
|
Xia
|
2000
|
|
|
Transgenic mice models with AMPAR internalisation defects attenuated LTD, although normal basic motor functions and no impairment of VOR adaptation
|
Schonewille
|
2011
|
|
|
10ms delay in somatic current injections could incur LTD or LTP depending on pairing (post-pre or pre-post)
|
Markram
|
1997
|
Somatic current injection into bidirectionally connected cells
|
|
STDP in xenopus retinotectal synaptic circuit
|
Zhang
|
1998
|
|
|
STDP can influence sensory receptive field
|
Vislay-Meltzer
|
2006
|
Mapped receptive fields of xenopus tectal neurons, flashes of light on retina paired with injection of somatic current
|
|
Application of DA can convert LTD to LTP or reverse LTD depending on timing
|
Brzosko
|
2015
|
Schaffer-collateral CA1 pathway
|
|
STDP in the pre-post pairing of place cells
|
Meha
|
1997
|
Mice trained to run unidirectionally, specific cells fired in sequence
|
|
STDP in inhibitory GABAergic synapses
|
Woodin
|
2008
|
|
|
STDP in converging inhibitory and excitatory inputs
|
D'amour
|
2015
|
IPSCs/ EPSCs paired with postsynaptic APs respectively
|
|
Dendritic spikes are required for LTP
|
Remy
|
2007
|
TTX applied to soma, dendritic spikes recorded in neurons displaying LTP
|
|
No change in LTP when TTX applied to soma and axon
|
Hardie
|
2009
|
Stratum radiatum
|
|
NMDAR blocker prevented LTP
|
Collingridge
|
1983
|
AP-5 applied in SC-CA1 pathway (rats)
|
|
EGTA (calcium chelator) blocked LTP
|
Lynch
|
1983
|
|
|
Intracellular photolysis of calcium caging compound was enough to induce LTP
|
Malenka
|
1988
|
|
|
Inhibition of CaMKII prevents induction of LTP
|
Silva
|
1992
|
CaMKII inhibitory peptide, mice with loss-of-function CaMKII mutation
|
|
Activation of postsynaptic CaMKII sufficient to induce LTP
|
Lledo
|
1995
|
Postsynaptic injection of preactivated CaMKII monomers
|
|
CaMKII not required for LTP maintenance
|
Malinow
|
1989
|
CaMKII inhibitor added after induction of LTP
|
|
Atypic PKC inhibitor returned EPSP to baseline after LTP induction
|
Ling
|
2005
|
|
|
PKMzeta KO mice had normal LTP
|
Volk
|
2013
|
|
|
LTP increases transmitter release
|
Zakharenko
|
2003
|
FM1-43 dye (becomes fluorescent when integrated with membrane phospholipids
|
|
Calcium transients increased significantly after LTP induction
|
Emptage
|
2003
|
Calcium transients as indicators of release probability
|
|
When GluR1 AMPARs coexpressed with CaMKII, increased conductance
|
Derkrach
|
1999
|
Patch-clamp recordings
|
|
Isolated NMDAR-only cells; found AMPAR-EPSCs after LTP induction
|
Isaac
|
1995
|
|
|
AMPARs seen redistributed to dendritic spine surfaces
|
Shi
|
1999
|
GluR-1-GFP, electron microscopy
|
|
Most SC-CA1 have coexpression of NMDAR and AMPAR
|
Racca
|
2010
|
Immunogold NMDAR/AMPAR labelling
|
