Statistics for Sentinel cells

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Hint	Answer	% Correct
How many functional TLR genes do humans have?	10	100%
What cytokine is a major example of this and also induces the acute phase response?	IL-6	100%
What is another example of one, that increases vascular permeability, but if systemically released may acumulate to shock?	TNF-alpha	100%
Two downstream molecules are normally activate when TLRs are NF kappaB is one whats the other?	AP-1	50%
Sentinel cells play a major role in sensing damage and infection, there are three key one, mast cells, macrophages and what third?	Dendritic	50%
What is the group name given to cytokines that induce fever?	Endogenous pyrogens	50%
Odd numbered TLRs are not found on the cell surface, so where are they found?	Endosomes	50%
What specific type of bacteria is this ligand found in the membrane of?	Gram negative	50%
Sometimes the cytosolic receptors link together to form a polymer, which can be used to activate caspase 1 which then activates IL-1beta, what is the name of the polymer?	Inflammasome	50%
One specific PRR is Toll Like Receptor 4, what is the specific ligand that it recognises?	LPS	50%
Finally which recognise cytosolic molecules?	NOD-like receptors	50%
They express pattern recognition receptors to recognise what molecules?	PAMPs/DAMPs	50%
And which are important in viral infections?	RIG-I-Like receptors	50%
NOD2 is a type of PRR what disease is associated with mutations in it?	Crohn's	0%
There are other families of PRR, which are important in fungal infections?	C-type Lectin receptors	0%