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pharmacology - multi choice practice exam
literally the practice exam in quiz form
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Last updated: May 26, 2023
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| First submitted | May 25, 2023 |
| Times taken | 50 |
| Average score | 47.5% | Report this quiz | Report |
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1.
Donepezil is an enzyme inhibitor used in the treatment of Alzheimer’s disease. Which enzyme does it act on?
Cyclo-oxygenase
✓
Acetylcholinesterase
✓
Adenylyl cyclase
✓
Phosphodiesterase
✓
2.
Which of the following is NOT an effect of insulin on lipids and fat fuel homeostasis?
Increases lipoprotein lipase activity
✓
Increases fat storage in adipocytes
✓
Increases lipolysis
✓
Increases hepatic lipoprotein synthesis
✓
3.
On which cell type in the stomach does pantoprazole act?
Parietal cells
✓
Chief cells
✓
Smooth muscle cells
✓
Goblet cells
✓
4.
Levodopa, a metabolic precursor of dopamine is used as a primary treatment for Parkinsonism. Which levodopa metabolism inhibitor drug is it normally combined with?
Biperiden
✓
Bromocriptine
✓
Carbidopa
✓
Benztropine
✓
5.
How does galantamine exert its anti-Alzheimers actions?
It interacts with the amyloid precursor protein dissolving the amyloid plaques.
✓
It binds to the tau protein destabilising the neurofibrillary tangles.
✓
It enhances the levels of synaptic acetylcholine by inhibiting the acetylcholinesterase enzyme.
✓
It promotes the production of new cortical neurons.
✓
6.
Zolpidem (Stilnox) binds to the omega-1 modulatory site found on which receptor?
The glutamate receptor
✓
The aspartate receptor
✓
The glycine receptor
✓
The GABA-A receptor
✓
7.
Which of the following statements regarding the benzodiazepine class of drugs is UNTRUE?
Binding of benzodiazepines to its receptor results in neuronal cell hyperpolarisation
✓
Benzodiazepines can be used to treat a variety of sleep disorders
✓
Benzodiazepines all have similar durations of action
✓
At high doses BZPs relax the spasticity of skeletal muscle by increasing presynaptic inhibition in the spinal cord via GABAB receptors.
✓
8.
Which of the following neurotransmitters does not contribute to mood elevation when levels are raised in neuronal synapses?
Noradrenaline
✓
Acetylcholine
✓
Dopamine
✓
Serotonin
✓
9.
Which of the following antidepressant drugs exerts its effects by acting as a monoamine oxidase inhibitor (MAOI)?
Amitriptyline
✓
Venlafaxine
✓
Phenelzine
✓
Fluoxetine
✓
10.
Which of the following bronchodilators belongs to the anticholinergic class of drugs?
Ipratropium
✓
Salmeterol
✓
Theophylline
✓
Adrenaline
✓
11.
How does the anti-asthma drug cromolyn exert its anti-inflammatory action?
It is a mast-cell stabiliser preventing the release of inflammatory mediators such as histamine
✓
It is a 5-lipoxygenase inhibitor blocking the production of leukotriene LT4 from arachidonic acid
✓
It is a cysLT1 receptor blocker
✓
It is a corticosteroid and reduces the number and activity inflammatory cells in the airway
✓
12.
Which of the following monoclonal antibodies is an anti-inflammatory agent used in the treatment of asthma ?
Abciximab
✓
Traztuzumab
✓
Infliximab
✓
Omalizumab
✓
13.
Phenylephrine, a nasal decongestant used in the treatment of allergic rhinitis (hayfever), exerts its effects by acting as:
A selective alpha 1 adrenergic receptor agonist
✓
A selective alpha 1 adrenergic receptor antagonist
✓
A selective alpha 2 adrenergic receptor agonist
✓
A selective alpha 2 adrenergic receptor antagonist
✓
14.
How does novocaine exert it’s effects as a local anaesthetic ?
It opens neuronal sodium ion channels
✓
It blocks neuronal sodium ion channels
✓
It potentiates neurotransmitter uptake from the synapse
✓
It blocks neurotransmitter uptake from the synapse
✓
15.
Which of the following statements is TRUE concerning the posterior pituitary gland?
Anti-diuretic hormone is synthesised in the hypothalamus and transported to the posterior pituitary where it is stored
✓
Anti-diuretic hormone is synthesised and stored in the posterior pituitary gland
✓
Anti-diuretic hormone is synthesised in the anterior pituitary transported to the posterior pituitary where it is stored
✓
Anti-diuretic hormone is synthesised in the posterior pituitary and transported to the anterior pituitary where it is stored
✓
16.
Propylthiouricil is indicated for Graves’ disease. How does it exert its therapeutic effect?
It inhibits synthesis of thyroid hormone by blocking the uptake of the iodide ion into the thyroid cell
✓
It inhibits synthesis of thyroid hormone by inhibiting the synthesis of thyroglobulin
✓
It inhibits synthesis of thyroid hormone by inhibiting the iodination process
✓
It inhibits synthesis of thyroid hormone by blocking the proteolytic release
✓
17.
Overproduction of growth hormone in an adult leads to?
Dwarfism
✓
Gigantism
✓
Type 2 diabetes mellitus
✓
Acromegaly
✓
18.
Decrease in the levels of vasopressin (ADH) results in
Diabetes Insipidus
✓
Type 1 diabetes mellitus
✓
Type 2 diabetes mellitus
✓
Type 3 diabetes mellitus
✓
19.
Which drug class does the anti-cancer drug, bleomycin belong to?
Alkylating agent
✓
Microtubule inhibitor
✓
Antimetabolite
✓
Antibiotic
✓
20.
Paclitaxel is a drug used to treat non-small cell lung cancer. What is its mechanism of action?
It is an alkylating agent that exert its cytotoxic effects by an alkylation that cross-links strands of DNA to inhibit its replication and, eventually, RNA and protein synthesis
✓
It is a mustard agent that is converted by a series of reactions in the liver to its active forms (phosphoramide mustard and acrolein) which interferes with the growth of susceptible cancer cells
✓
It stabilises microtubules by preventing depolymerisation resulting in the inhibition of the normal dynamic reorganisation of the microtubule network essential for cellular functions
✓
It binds to tubulin blocking formation of microtubules thus inhibiting mitosis and ultimately cell division
✓
21.
Which of the following is NOT classified as a naked monoclonal antibody for use in cancer therapy?
Rituximab ozogamicin
✓
Gemtuzumab ozogamicin
✓
Trastuzumab ozogamicin
✓
Alemtuzumab ozogamicin
✓
22.
Which of the following statements is true with regards to the opioid class of drugs?
The depressant actions of opioids are decreased by interaction of monoamine oxidase inhibitors
✓
Opioids have a tussive effect, causing cough to occur
✓
Opioids decrease the motility and increases the tone of intestinal smooth muscle stopping diarrhoea
✓
All opioids are derived from the opium poppy
✓
23.
Which of the following is used to reverse an opioid overdose?
Naloxone
✓
Morphine
✓
Buprenorphine
✓
Methadone
✓
24.
Which of the following is TRUE about the anti-influenza drug zanamivir (Relenza)?
It is a vaccine
✓
It is an M2 inhibitor
✓
It is an IMP dehydrogenase inhibitor
✓
It is a neuraminidase inhibitor
✓
25.
How does aspirin exert it’s antiplatelet action?
It is a COX inhibitor
✓
It is a GP IIb/IIIa inhibitor
✓
It is an ADP antagonist
✓
It is a phosphodiesterase inhibitor
✓
26.
Which enzyme is the molecular target for the anticoagulant, warfarin?
Vitamin A oxide reductase
✓
Vitamin D oxide reductase
✓
Vitamin E oxide reductase
✓
Vitamin K oxide reductase
✓
27.
Which of the following is a member of the thiazolidinedione class of insulin sensitisers used in the treatment of type II diabetes?
Glargine insulin
✓
Metformin
✓
Pioglitazone
✓
Tolbutamide
✓
28.
Which of the following drugs can be used to help prevent convulsions in pregnancy?
Magnesium sulphate
✓
Salbutamol
✓
Atosiban
✓
Propanolol
✓
29.
Which of the following antibiotic groups does NOT belong to beta lactam class?
Tetracyclines
✓
Penicillins
✓
Cephalosporins
✓
Carbapenems
✓
30.
Successful molecular therapy has been achieved with a number of genetic diseases. The gene for which enzyme has been successfully introduced into bone marrow as a treatment for patients with severe combined immunodeficiency (bubble boy disease)
Adenylyl cyclase
✓
Adenosine deaminase
✓
Adenosine cyclase
✓
Adenyl deaminase
✓
31.
Which of the following statements is FALSE with respect to the H5N1 avian influenza virus?
There is difficulty of transmission between birds halting potential global spread
✓
There is mutation into a variety of virulent strains with differing pathological profiles
✓
A wide range of hosts able to be infected allowing for greater spread of the disease
✓
It has a high mutation rate
✓
32.
The Oxford-Astra Zeneca vaccine, currently being used in Australia to combat COVID- 19 infections, belongs to which vaccine type?
RNA vaccine
✓
Conventional inactivated vaccine
✓
Protein subunit vaccine
✓
Viral vector vaccine
✓
33.
Which of the following is the definition of pharmacological tolerance?
The recurrent use of substances that are illegal or that cause harm to the individual
✓
The condition in which drug taking becomes compulsive, taking precedence over other needs
✓
The physiological and psychological adverse effects associated with sudden cessation of drug use
✓
The decrease in pharmacological effect upon repeated administration of a drug
✓
34.
CB1 cannabinoid receptors belong to which class of membrane receptors?
Gs-linked G protein-coupled receptors
✓
Gi-linked G protein-coupled receptors
✓
Receptor tyrosine kinases
✓
Ionotropic receptors
✓
35.
Anandamide belongs to which class of cannabinoid molecules?
Endocannabinoids
✓
Phytocannabinoids
✓
Synthetic cannabinoids
✓
White powder cannabinoids
✓
36.
Which of the following opioids is not present in the opium poppy?
Morphine
✓
Codeine
✓
Heroin
✓
Thebaine
✓
37.
Osmotic diarrhoea is an adverse effect associated with which of the following antacids?
Sodium bicarbonate
✓
Calcium carbonate
✓
Magnesium hydroxide
✓
Aluminium hydroxide
✓
38.
Which of the following human insulin and insulin analogues has the most rapid onset of action
Regular insulin
✓
Glargine insulin
✓
Extended zinc insulin
✓
Lispro insulin
✓
39.
Which of the following is not a common gastrointestinal tract adverse effect associated with NSAIDs such as aspirin?
Constipation
✓
Gastric irritation
✓
Peptic ulcers
✓
Bleeding
✓
40.
Probenecid is used as a treatment for gout. Probenecid exerts its effects by:
Inhibits uric acid synthesis
✓
Increases uric acid excretion
✓
Inhibits leukocyte entry into the joints
✓
Reducing inflammatory pain
✓
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