Hint (Description or Effect)
|
Answer
|
???
|
Blank Rune
|
Void
|
Black Rune
|
It still glows faintly
|
Rune Shard
|
Reroll... or not
|
Soul of Isaac
|
Give me your love!
|
Soul of Magdalene
|
Opens the unopenable
|
Soul of Cain
|
Right behind you
|
Soul of Judas
|
Chemical warfare
|
Soul of ??? (Blue Baby)
|
You very own murder
|
Soul of Eve
|
Slay a thousand
|
Soul of Samson
|
Demon rage!
|
Soul of Azazel
|
Life after death
|
Soul of Lazarus
|
Embrance chaos
|
Soul of Eden
|
Leave your body behind
|
Soul of the Lost
|
Motherhood
|
Soul of Lilith
|
$$$
|
Soul of the Keeper
|
Bringer of calamity
|
Soul of Apollyon
|
Skeletal protector
|
Soul of the Forgotten
|
Friends from beyond
|
Soul of Bethany
|
Bound by blood
|
Soul of Jacob and Esau
|
D6 + D20
|
Dice Shard
|
Help from above
|
Emergency Contact
|
???
|
Cracked Key
|
Isaac farts, dealing 5 damage and poisoning enemies
|
Bad Gas
|
Deals a full heart of damage
|
Bad Trip
|
Grants Isaac two soul hearts
|
Balls of Steel
|
Swaps the values of Isaac's bombs and keys
|
Bombs Are Key
|
Spawns a lit bomb behind Isaac
|
Explosive Diarrhea
|
Refills every empty red hearts
|
Full Health
|
Removes one red heart container
|
Health Down
|
Adds one empty red heart container
|
Health Up
|
...and ate them
|
I Found Pills
|
Causes Isaac to grow hairs
|
Puberty
|
Grants a fly orbital, up to 3 maximum
|
Pretty Fly
|
-1.00 range
|
Range Down
|
+1.25 range
|
Range Up
|
-0.12 speed
|
Speed Down
|
+0.12 speed
|
Speed Up
|
-0.28 tears
|
Tears Down
|
+0.28 tears
|
Tears Up
|
-1 luck
|
Luck Down
|
+1 luck
|
Luck Up
|
Teleports Isaac to a random room
|
Telepills
|
Drops one to two Lil' Batteries and fully charges the active item
|
48 Hour Energy
|
Sets Isaac's red heart health to 1, and spawns 1-4 red hearts
|
Hematemesis
|
Prevents Isaac from moving and shooting for 2 seconds
|
Paralysis
|
Opens all entrances to the (Super) Secret Room for the current floor
|
I can see forever!
|
Charms all enemies in the room for a short period of time.
|
Pheromones
|
Gives "Curse of the Lost"
|
Amnesia
|
Spawns a large yellow pool around Isaac
|
Lemon Party
|
Tears are shot diagonally outwards for 30 seconds
|
R U a Wizard?
|
For the duration of the room, taking damage only removes a half heart from Isaac's HP
|
Percs!
|
For the duration of the room, taking damage removes a full heart from Isaac's HP
|
Addicted!
|
Spawns Poop at Isaac's position for a few seconds.
|
Re-Lax
|
Gives "Curse of the Maze"
|
??? (Question Question Question)
|
Increases Isaac's size
|
One makes you larger
|
Decreases Isaac's size
|
One makes you small
|
Destroys all poop in the room and spawns a single blue spider under Isaac and on each destroyed poop
|
Infested!
|
Spawns blue spiders equal to the number of enemies in the room
|
Infested?
|
Similar to "The Gamekid" item.
|
Power Pill!
|
Pixelates the screen and degrades colors for 30 seconds
|
Retro Vision
|
Spawns three blue flies
|
Friends Till The End!
|
Creates a pool of brown creep
|
X-Lax
|
Creates a pool of black creep
|
Something's wrong...
|
Applies the "Stop Watch" effect for the duration of the room
|
I'm Drowsy...
|
Increases the speed of all enemies, Isaac, and the background music for the duration of the room
|
I'm Excited!!!
|
Destroys any trinkets held by Isaac and grants their effects permanently
|
Gulp!
|
Isaac shoots an explosive tears with the Ipecac effect
|
Horf!
|
Temporarity makes Isaac invincible
|
Feels like I'm walking on sunshine!
|
Spawns the last pill used
|
Vurp!
|
-0.15 shot speed
|
Shot Speed Down
|
+0.15 shot speed
|
Shot Speed Up
|
Increases one stat and decreases another randomly
|
Experimental Pill
|