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pharmacokinetic equations

Quiz by camisadorising
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Last updated: April 19, 2023
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First submittedApril 19, 2023
Times taken27
Average score60.0%
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Hint
Answer
Four hours after intravenous administration of a drug, a patient was found to have a drug plasma concentration of 60 μg/mL. Assuming the apparent volume of distribution is 10% of an average body weight of 90 kg, calculate the total amount of drug present in body fluids four hours after administration.
540 mg
Four hours after intravenous administration of a drug, a patient was found to have a drug plasma concentration of 30 μg/mL. Assuming the apparent volume of distribution is 10% of an average body weight of 75 kg, calculate the total amount of drug present in body fluids four hours after administration.
225 mg
Calculate the elimination rate constant for a drug having an elimination half-life of 36 minutes.
1.16/hr
What is the plasma concentration of a drug when 900 mg is given by IV bolus to a 100kg patient if her volume of distribution is 7.7L/kg.
1.169 mg/L
Assuming complete absorption and an elimination half-life of 4 hours, how many mg of a drug will remain in the body 25 hours after administering a 100 mg dose?
1.314 mg
Hint
Answer
What is the plasma concentration of a drug when 200 mg is given by IV bolus to a 65kg patient if her volume of distribution is 16 L/kg.
0.192 mg/L
The volume of distribution of a drug is 19 L with a blood concentration of 3 mg/L. Calculate the total amount of drug present in the patient.
57 mg
A drug has an elimination rate constant of 0.702 hr-1. Its elimination half-life is:
0.99 hrs
If 975mg of a drug is administered orally and 95mg is absorbed unchanged, the bioavailability of the drug is:
0.097 or 9.7%
Assuming complete absorption and an elimination half-life of 10 hours, how many mg of a drug will remain in the body 60 hours after administering a 650 mg dose?
10.156 mg
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