pharmacokinetic equations

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Last updated: April 19, 2023

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First submitted	April 19, 2023
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Hint	Answer
Assuming complete absorption and an elimination half-life of 5 hours, how many mg of a drug will remain in the body 35 hours after administering a 400 mg dose?	3.125 mg
The area under the serum concentration-time curves (AUC) were measured after single doses of 10 mg of a new antihypertensive drug were administered in hypertensive patients. The results were as follows: intravenous bolus AUC = 2500 mg . h/L, oral capsule AUC = 500 mg . h/L, oral liquid AUC = 650 mg . h/L. What is the bioavailability of the oral liquid?	0.26 or 26.0%
Assuming complete absorption and an elimination half-life of 10 hours, how many mg of a drug will remain in the body 60 hours after administering a 650 mg dose?	10.156 mg
What is the plasma concentration of a drug when 400 mg is given by IV bolus to a 100kg patient if her volume of distribution is 54 L/kg.	0.074 mg/L
The area under the serum concentration-time curves (AUC) were measured after single doses of 10 mg of a new antihypertensive drug were administered in hypertensive patients. The results were as follows: intravenous bolus AUC = 7300 mg . h/L, oral capsule AUC = 500 mg . h/L, oral liquid AUC = 940 mg . h/L. What is the bioavailability of the oral liquid?	0.128 or 12.8%
Calculate the elimination rate constant for a drug having an elimination half-life of 54 minutes.	0.77/hr
Calculate the elimination rate constant for a drug having an elimination half-life of 15 minutes.	2.77/hr
A drug has an elimination rate constant of 0.296 hr-1. Its elimination half-life is:	2.34 hrs
A single intravenous dose of 40 mg of diazepam was administered to a patient. A blood sample was drawn and it contained 50 µg/mL. Calculate the apparent volume of distribution for the drug.	0.8 L
A drug has an elimination rate constant of 0.702 hr-1. Its elimination half-life is:	0.99 hrs